Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Autor: Bf, Verhaaren, Debette S, Jc, Bis, Ja, Smith, Mk, Ikram, Hh, Adams, Ah, Beecham, Kb, Rajan, Lm, Lopez, Barral S, Ma, Buchem, van der Grond J, Av, Smith, Hegenscheid K, Nt, Aggarwal, de Andrade M, Ej, Atkinson, Beekman M, As, Beiser, Sh, Blanton, Boerwinkle E, Am, Brickman, Rn, Bryan, Chauhan G, Cp, Chen, Chouraki V, Aj, Craen, Crivello F, Ij, Deary, Deelen J, Pl, Jager, Dufouil C, Ms, Elkind, Da, Evans, Freudenberger P, Rf, Gottesman, Guðnason V, Habes M, Sr, Heckbert, Heiss G, Hilal S, Hofer E, Hofman A, Ca, Ibrahim-Verbaas, Ds, Knopman, Ce, Lewis, Liao J, Dc, Liewald, Luciano M, van der Lugt A, Oo, Martinez, Mayeux R, Mazoyer B, Ma, Nalls, Nauck M, Wj, Niessen, Ba, Oostra, Bm, Psaty, Km, Rice, Ji, Rotter, von Sarnowski B, Schmidt H, Pj, Schreiner, Schuur M, Ss, Sidney, Sigurdsson S, Pe, Slagboom, Dj, Stott, Jc, Swieten, Teumer A, Am, Töglhofer, Traylor M, Trompet S, St, Turner, Tzourio C, Hw, Uh, Ag, Uitterlinden, Mw, Vernooij, Jj, Wang, Ty, Wong, Jm, Wardlaw, Bg, Windham, Wittfeld K, Wolf C, Cb, Wright, Yang Q, Zhao W, Zijdenbos A, Jw, Jukema, Rl, Sacco, Sl, Kardia, Amouyel P, Th, Mosley, Wt, Longstreth Jr, Cc, Decarli, Cm, Duijn, Schmidt R, Lj, Launer, Hj, Grabe, Ss, Seshadri, Ma, Ikram, Fornage M

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a3113d3796b454ac9b7f1a85213d0598
http://europepmc.org/abstract/med/25663218

Statistical integration of multi-omics and drug screening data from cell lines.

Autor: El Bouhaddani S; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands., Höllerhage M; Department of Neurology, Hannover Medical School, Hannover, Germany., Uh HW; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands., Moebius C; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Bickle M; Roche Institute for Translational Bioengineering, Basel, Switzerland., Höglinger G; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, Ludwig-Maximilians-Universität, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Houwing-Duistermaat J; Dept. Data science & Biostatistics, UMC Utrecht, Utrecht, Netherlands.; Dept. of Mathematics, Radboud University, Nijmegen, Netherlands.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2024 Jan 31; Vol. 20 (1), pp. e1011809. Date of Electronic Publication: 2024 Jan 31 (Print Publication: 2024).

Smartphone detection of atrial fibrillation using photoplethysmography: a systematic review and meta-analysis.

Autor: Gill S; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK s.gill.5@bham.ac.uk.; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Bunting KV; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Sartini C; Medical Affairs and Pharmacovigilance, Pharmaceuticals, Integrated Evidence Generation, Bayer AG, Leverkusen, Nordrhein-Westfalen, Germany., Cardoso VR; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Ghoreishi N; Medical Affairs and Pharmacovigilance, Pharmaceuticals, Integrated Evidence Generation, Bayer AG, Leverkusen, Nordrhein-Westfalen, Germany., Uh HW; Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, Netherlands., Williams JA; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Suzart-Woischnik K; Medical Affairs and Pharmacovigilance, Pharmaceuticals, Integrated Evidence Generation, Bayer AG, Leverkusen, Nordrhein-Westfalen, Germany., Banerjee A; Farr Institute of Health Informatics Research, University College London, London, UK., Asselbergs FW; Department of Cardiology, University Medical Centre Utrecht Department of Cardiology, Utrecht, Netherlands.; Department of Cardiology, University College London Faculty of Population Health Sciences, London, UK.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Eijkemans M; Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, Netherlands., Gkoutos GV; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Kotecha D; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.; Health Data Research UK Midlands Site, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Department of Cardiology, University Medical Centre Utrecht Department of Cardiology, Utrecht, Netherlands.

Publikováno v: Heart (British Cardiac Society) [Heart] 2022 Sep 26; Vol. 108 (20), pp. 1600-1607. Date of Electronic Publication: 2022 Sep 26.

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.

Autor: Pei J; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Department of Nephrology and Hypertension, DIG-D, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Schuldt M; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Nagyova E; Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands., Gu Z; Department of Biostatistics and Research Support, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., El Bouhaddani S; Department of Biostatistics and Research Support, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Yiangou L; Department of Anatomy and Embryology, LUMC, Leiden, The Netherlands., Jansen M; Department of Genetics, Division of Laboratories, Pharmacy and Biomedical Genetics, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Calis JJA; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands., Dorsch LM; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Blok CS; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands., van den Dungen NAM; Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands., Lansu N; Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands., Boukens BJ; Department of Medical Biology, AMC, Amsterdam, The Netherlands., Efimov IR; Department of Biomedical Engineering, GWU, Washington, DC, USA., Michels M; Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands., Verhaar MC; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Department of Nephrology and Hypertension, DIG-D, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., de Weger R; Department of Pathology, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Vink A; Department of Pathology, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., van Steenbeek FG; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands., Baas AF; Department of Genetics, Division of Laboratories, Pharmacy and Biomedical Genetics, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Davis RP; Department of Anatomy and Embryology, LUMC, Leiden, The Netherlands., Uh HW; Department of Biostatistics and Research Support, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., Kuster DWD; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Cheng C; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Department of Nephrology and Hypertension, DIG-D, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands.; Department of Biomedical Engineering, GWU, Washington, DC, USA., Mokry M; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Utrecht, The Netherlands.; Division of Paediatrics, UMC Utrecht, University of Utrecht, Utrecht, The Netherlands., van der Velden J; Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Asselbergs FW; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands. f.w.asselbergs@umcutrecht.nl.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK. f.w.asselbergs@umcutrecht.nl.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK. f.w.asselbergs@umcutrecht.nl.; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Room E03.818, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. f.w.asselbergs@umcutrecht.nl., Harakalova M; Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands. m.harakalova@umcutrecht.nl.; Regenerative Medicine Utrecht (RMU), University Medical Center Utrecht, University of Utrecht, 3584 CT, Utrecht, The Netherlands. m.harakalova@umcutrecht.nl.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2021 Mar 23; Vol. 13 (1), pp. 61. Date of Electronic Publication: 2021 Mar 23.

Investigating the impact of Down syndrome on methylation and glycomics with two-stage PO2PLS.

Autor: Gu Z; Dept. of Data Science and Biostatistics, Julius Centre, UMC Utrecht, The Netherlands. z.gu@umcutrecht.nl, Corresponding Author., El Bouhaddani S; Dept. of Data Science and Biostatistics, Julius Centre, UMC Utrecht, The Netherlands., Houwing-Duistermaat J; Dept. of Statistics, University of Leeds, The United Kingdom. Dept. of Data Science and Biostatistics, Julius Centre, UMC Utrecht, The Netherlands. Dept. of Statistical Sciences, University of Bologna, Italy., Uh HW; Dept. of Data Science and Biostatistics, Julius Centre, UMC Utrecht, The Netherlands.

Publikováno v: Theoretical biology forum [Theor Biol Forum] 2021 Jan 01; Vol. 114 (1-2), pp. 29-44. Date of Electronic Publication: 2021 Jan 01.