Výsledky vyhledávání - "Huzoor-Akbar"

Akademický článek

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

Autor: Xin Duan, Rehana Perveen, Akhila Dandamudi, Reheman Adili, James Johnson, Kevin Funk, Mark Berryman, Ashley Kuenzi Davis, Michael Holinstat, Yi Zheng, Huzoor Akbar

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Gene targeting of Cdc42 GTPase has been shown to inhibit platelet activation. In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate plate

Externí odkaz: https://doaj.org/article/4e0ab58442d54fbc9bafc38cdf9a72ae

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Supplementary Figure 1 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 70KB, WZB117 inhibited cell proliferation of cancer cells more than non-cancerous cells and exhibited synergy with anticancer drugs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe21e20ca47467f05450bc275e2a7b0
https://doi.org/10.1158/1535-7163.22498572

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Supplementary Figure Legend from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 61KB.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d834ca6cdb21ec6edc6c4531616c35f
https://doi.org/10.1158/1535-7163.22498563.v1

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Supplementary Table 1 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 122KB, Body composition of WZB117 treated tumor-bearing mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb748f7aecd6ba4893f53f7da080a1f
https://doi.org/10.1158/1535-7163.22498560.v1

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Supplementary Figure 2 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 149KB, Body weight and blood glucose levels of tumor-bearing mice treated by WZB117.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655b4bc303a00068145bfad12946477a
https://doi.org/10.1158/1535-7163.22498569

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Supplementary Table 2 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 129KB, Blood analysis of WZB117-treated tumor-bearing mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a1cbac15a9ea3e6bca0b3c2d18f3b8
https://doi.org/10.1158/1535-7163.22498557

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Supplementary Figure 3 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Autor: Xiaozhuo Chen, Jennifer Hines, Shiyong Wu, Lingying Tong, Juan Ding, Robert Colvin, Huzoor Akbar, Yanrong Qian, Stephen Bergmeier, Weihe Zhang, Yanyan Cao, Yi Liu

PDF file, 168KB, Intracellular ATP concentrations under different doses of extracellular ATP. time-dependence of extracellular ATP rescue of WZB117-treated cancer cells, and WZB117-induced autophagy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11152fe67bb2ce86485e4abfb7e4fb76
https://doi.org/10.1158/1535-7163.22498566.v1

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Akademický článek

RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets.

Autor: Huzoor Akbar, Xin Duan, Saima Saleem, Ashley K Davis, Yi Zheng

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163227 (2016)

Agonist induced generation of reactive oxygen species (ROS) by NADPH oxidases (NOX) enhances platelet aggregation and hence the risk of thrombosis. RhoA and Rac1 GTPases are involved in ROS generation by NOX in a variety of cells, but their roles in

Externí odkaz: https://doaj.org/article/a6b5e76a71e947929761241f7342f690

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Structure–Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

Autor: Akhila Dandamudi, William Seibel, Benjamin Tourdot, Jose A. Cancelas, Huzoor Akbar, Yi Zheng

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 4167

Current antiplatelet therapies have several clinical complications and are mostly irreversible in terms of suppressing platelet activity; hence, there is a need to develop improved therapeutic agents. Previous studies have implicated RhoA in platelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a9a530d1d65778844cf31c78110b65
https://doi.org/10.3390/ijms24044167

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Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies

Autor: Akhila Dandamudi, Huzoor Akbar, Jose Cancelas, Yi Zheng

Publikováno v: International Journal of Molecular Sciences. 24:2519

Platelets play a vital role in regulating hemostasis and thrombosis. Rho GTPases are well known as molecular switches that control various cellular functions via a balanced GTP-binding/GTP-hydrolysis cycle and signaling cascade through downstream eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fad11450c9b066ff4a9664edf9daa13
https://doi.org/10.3390/ijms24032519

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