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G-quadruplexes are noncannonical four-stranded DNA or RNA structures formed by guanine-rich repeating sequences. Guanine nucleotides can hydrogen bond to form a planar tetrad structure. Such tetrads can stack to form quadruplexes of various molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b942deb91133e79c59d7808ca94146
https://europepmc.org/articles/PMC5705227/
https://europepmc.org/articles/PMC5705227/
Publikováno v:
The Journal of Physical Chemistry. B
Guanine-rich oligonucleotides can adopt noncanonical tertiary structures known as G-quadruplexes, which can exist in different forms depending on experimental conditions. High-resolution structural methods, such as X-ray crystallography and NMR spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dee39e5860186cbeb7c245cbfd04c4
https://pubmed.ncbi.nlm.nih.gov/24779348
https://pubmed.ncbi.nlm.nih.gov/24779348
Autor:
Robert Buscaglia, Huy T. Le, Patrick A. Holt, Jonathan B. Chaires, M. Clarke Miller, William L. Dean, John O. Trent
Publikováno v:
Organicbiomolecular chemistry. 10(47)
G-quadruplexes, DNA tertiary structures highly localized to functionally important sites within the human genome, have emerged as important new drug targets. The putative G-quadruplex-forming sequence (Pu27) in the NHE-III(1) promoter region of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130c047deaf113f97f20d533c833f6c0
https://pubmed.ncbi.nlm.nih.gov/23108607
https://pubmed.ncbi.nlm.nih.gov/23108607
Publikováno v:
Topics in Current Chemistry ISBN: 9783642347429
Nucleic acids enriched in guanine bases can adopt unique quadruple helical tertiary structures known as G-quadruplexes. G-quadruplexes have emerged as attractive drug targets as many G-quadruplex-forming sequences have been discovered in functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab07e12f4ac412d8f9c60d48bd4b196
https://doi.org/10.1007/128_2012_351
https://doi.org/10.1007/128_2012_351
Autor:
John O. Trent, William L. Dean, Jonathan B. Chaires, Patrick A. Holt, Huy T. Le, M. Clarke Miller
Publikováno v:
Organicbiomolecular chemistry. 9(22)
We report the separation of several quadruplex species formed by ten promoter sequences by Size Exclusion Chromatography (SEC). Modification at the 5′ or 3′ ends or in loop regions of quadruplex forming sequences has become the standard technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c1018f771a6a769ad4fe0f52614875
https://pubmed.ncbi.nlm.nih.gov/21938285
https://pubmed.ncbi.nlm.nih.gov/21938285
Autor:
Irina A. Smolenkova, Sarah A. Andres, Huy T Le, James L. Wittliff, D. Alan Kerr, Stefanie B. Bumpus
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691f46b12382fe49f3acef2f377575f8
https://doi.org/10.1096/fasebj.22.1_supplement.718.2
https://doi.org/10.1096/fasebj.22.1_supplement.718.2
Publikováno v:
Journal of Physical Chemistry B; May2014, Vol. 118 Issue 20, p5390-5405, 16p