Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Huy Pho"'
Autor:
Mateus R. Amorim, Xin Wang, O. Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Caitlin Ribeiro, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz G.S. Branco, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113512- (2023)
Summary: Mismatch between CO2 production (Vco2) and respiration underlies the pathogenesis of obesity hypoventilation. Leptin-mediated CNS pathways stimulate both metabolism and breathing, but interactions between these functions remain elusive. We h
Externí odkaz:
https://doaj.org/article/064f3471777a450ebee6538a74108129
Autor:
Michele L. Singer, Mi-Kyung Shin, Lenise J. Kim, Carla Freire, O Aung, Huy Pho, Joshua A. East, Frank P. Sgambati, Alban Latremoliere, Luu V. Pham, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Opioid-induced respiratory depression (OIRD) is the primary cause of death associated with opioids and individuals with obesity are particularly susceptible due to comorbid obstructive sleep apnea (OSA). Repeated exposure to opioids, as
Externí odkaz:
https://doaj.org/article/9310a03d6f3d40429e3f98cf74eea5e0
Autor:
Huy Pho, Mateus R. Amorim, Qingchao Qiu, Mi‐Kyung Shin, Lenise J. Kim, Frederick Anokye‐Danso, Jonathan J. Jun, Rexford S. Ahima, Luiz G. S. Branco, Donald M. Kuhn, Jason H. Mateika, Vsevolod Y. Polotsky
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract Serotonin is an important mediator modulating behavior, metabolism, sleep, control of breathing, and upper airway function, but the role of aging in serotonin‐mediated effects has not been previously defined. Our study aimed to examine the
Externí odkaz:
https://doaj.org/article/1ece876c7dc348f2a4ae1ffef2d3bac5
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/77a70a604ccf426098a2e423aa62b323
Autor:
Lenise J. Kim, Mi-Kyung Shin, Huy Pho, Laszlo Otvos, Sergio Tufik, Monica L. Andersen, Luu V. Pham, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundObesity can cause hypertension and exacerbates sleep-disordered breathing (SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate, suppresses appetite, modulates control of breathing, and increases blood pressure. Obe
Externí odkaz:
https://doaj.org/article/654bed9a103c4c73901704080baeaddc
Autor:
Thomaz A. Fleury Curado, Huy Pho, Olga Dergacheva, Slava Berger, Rachel Lee, Carla Freire, Aya Asherov, Luis U. Sennes, David Mendelowitz, Alan R. Schwartz, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Obstructive Sleep Apnea (OSA) is a prevalent condition and a major cause of morbidity and mortality in Western Society. The loss of motor input to the tongue and specifically to the genioglossus muscle during sleep is associated with pharyngeal colla
Externí odkaz:
https://doaj.org/article/661964a760ce4552bf904e4d0259d15d
Autor:
Yoichi Nishimura, Rafael S. Arias, Huy Pho, Luu Van Pham, Thomaz Fleury Curado, Vsevolod Y. Polotsky, Alan R. Schwartz
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Introduction: Invasive procedures were previously developed for measuring pharyngeal collapsibility in rodents during expiration, when declining neuromuscular activity makes the airway unstable. We developed a non-invasive approach for streamlining c
Externí odkaz:
https://doaj.org/article/fe1b3ce5460e484e959b536078bbc27e
Autor:
Carla Freire, Jacob D. Ramsey, Huy Pho, Ryo Kojima, Yuling Zhao, Lenise Kim, Frederick Anokye-Danso, Slava Berger, Rexford S. Ahima, Elena V. Batrakova, Alexander V. Kabanov, Vsevolod Y. Polotsky
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:720-723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686167dd99588d7110b9dad07c78b3e0
https://doi.org/10.1165/rcmb.2022-0229le
https://doi.org/10.1165/rcmb.2022-0229le
Autor:
Lenise J. Kim, Chloe Alexandre, Huy Pho, Alban Latremoliere, Vsevolod Y. Polotsky, Luu V. Pham
Publikováno v:
Journal of Applied Physiology. 133:1284-1294
Obesity is associated with sleep-disordered breathing (SDB) and unrefreshing sleep. Residual daytime sleepiness and sleep impairments often persist after SDB treatment in patients with obesity, which suggests an independent effect of obesity on breat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c6f6d2cd0341b3e70fcbac2927afdb
https://doi.org/10.1152/japplphysiol.00386.2022
https://doi.org/10.1152/japplphysiol.00386.2022
Autor:
Lenise J. Kim, Mi‐Kyung Shin, Huy Pho, Wan‐Yee Tang, Nishitha Hosamane, Frederick Anokye‐Danso, Rexford S. Ahima, James S. K. Sham, Luu V. Pham, Vsevolod Y. Polotsky
Publikováno v:
The Journal of Physiology. 600:5145-5162
Sleep-disordered breathing (SDB) affects over 50% of obese individuals. Exaggerated hypoxic chemoreflex is a cardinal trait of SDB in obesity. We have shown that leptin acts in the carotid bodies (CB) to augment chemoreflex and that leptin activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508d20f8f526ba2b2880c94802fb8af8
https://doi.org/10.1113/jp283678
https://doi.org/10.1113/jp283678