Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Huy N. Hoang"'
Autor:
Angela A. Salim, Waleed M. Hussein, Pradeep Dewapriya, Huy N. Hoang, Yahao Zhou, Kaumadi Samarasekera, Zeinab G. Khalil, David P. Fairlie, Robert J. Capon
Publikováno v:
Marine Drugs, Vol 21, Iss 9, p 487 (2023)
Application of a miniaturized 24-well plate system for cultivation profiling (MATRIX) permitted optimization of the cultivation conditions for the marine-derived fungus Talaromyces sp. CMB-TU011, facilitating access to the rare cycloheptapeptide tala
Externí odkaz:
https://doaj.org/article/42f42ea2be534df994531dff6bea61a8
Autor:
Chongyang Wu, Huy N. Hoang, Timothy A. Hill, Junxian Lim, W. Mei Kok, Kalyani Akondi, Ligong Liu, David P. Fairlie
Publikováno v:
Chemical Communications. 58:12475-12478
Cyclic peptides with esters but not N-methyl amides are the smallest known alpha helices in water and can enter cells.
Publikováno v:
Angewandte Chemie. 133:8466-8471
N- or C-methylation in natural and synthetic cyclic peptides can increase membrane permeability, but it remains unclear why this happens in some cases but not others. Here we compare three-dimensional structures for cyclic peptides from six families,
Publikováno v:
Angewandte Chemie (International ed. in English). 61(29)
Aromatic groups are key mediators of protein-membrane association at cell surfaces, contributing to hydrophobic effects and π-membrane interactions. Here we show electrostatic and hydrophobic influences of aromatic ring substituents on membrane affi
Autor:
David P. Fairlie, Timothy A. Hill, Chongyang Wu, Paul V. Bernhardt, Aline Dantas de Araujo, Huy N. Hoang, Ligong Liu
Publikováno v:
Angewandte Chemie International Edition. 58:18873-18877
The introduction of an amide bond linking side chains of the first and fifth amino acids forms a cyclic pentapeptide that optimally stabilizes the smallest known α-helix in water. The origin of the stabilization is unclear. The observed dependence o
Publikováno v:
RSC chemical biology. 3(7)
Cyclic peptides that modulate protein-protein interactions can be valuable therapeutic candidates if they can be delivered intact to their target proteins in cells. Here we systematically compare the effects of different helix-inducing cyclization co
Autor:
Timothy A. Hill, David P. Fairlie, Gloria Ruiz-Gómez, Frederik Diness, Nicholas E. Shepherd, Giovanni Abbenante, Huy N. Hoang, Jody M. Mason, Chongyang Wu
Publikováno v:
Chemical Science. 10:10595-10600
Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH2,
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59415 (2013)
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic
Externí odkaz:
https://doaj.org/article/79d79d2f77d44a0fb8774105cc86847a
Autor:
Paula M. Loria, Aline Dantas de Araujo, David Price, Adam J. Cotterell, David A. Griffith, Spiros Liras, Timothy A. Hill, David P. Fairlie, Weijun Xu, David R. Derksen, Robert V. Stanton, Fabien Plisson, Huy N. Hoang, Justin M. Mitchell, David J. Edmonds
Publikováno v:
European Journal of Medicinal Chemistry. 127:703-714
Glucagon-like peptide (GLP-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to treat diabetes mellitus type 2. Understanding how GLP-1 interacts with its receptor (GLP-1R) can potentially l
Autor:
Daniel S. Nielsen, Rink-Jan Lohman, Timothy A. Hill, W. Mei Kok, Huy N. Hoang, David P. Fairlie
Publikováno v:
Chemical communications (Cambridge, England). 55(89)
Rule-of-five parameters and membrane permeabilities have been routinely used to guide development of orally bioavailabile drugs. Here we compare enantiomeric pairs of cyclic hexapeptides with identical rule-of-five parameters and membrane permeabilit