Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Huxley K, Hoffman"'
1
HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells
Autor: Huxley K. Hoffman, Rytis Prekeris
Publikováno v: bioRxiv
Primary cilia are sensory cellular organelles crucial for organ development and homeostasis. Ciliogenesis in polarized epithelial cells requires Rab19-mediated clearing of apical cortical actin to allow the cilium to grow from the apically-docked bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e17e71d621ab0831c46d9cf536c33c9
https://doi.org/10.1101/2023.02.07.527563
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2
Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines
Autor: Melissa V. Fernandez-de Céspedes, Huxley K. Hoffman, Hannah Carter, Lacy M. Simons, Lwar Naing, Sherimay D. Ablan, David A. Scheiblin, Judd F. Hultquist, Schuyler B. van Engelenburg, Eric O. Freed
Publikováno v: Journal of Virology. 96
The incorporation of the HIV-1 envelope (Env) glycoproteins, gp120 and gp41, into virus particles is critical for virus infectivity. gp41 contains a long cytoplasmic tail that has been proposed to interact with host cell factors, including the traffi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93a9e531c1bc5402f8d054a9ae039de7
https://doi.org/10.1128/jvi.00876-22
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3
Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4
Autor: Melissa V, Fernandez-de Céspedes, Huxley K, Hoffman, Hannah, Carter, Lacy M, Simons, Lwar, Naing, Sherimay D, Ablan, David A, Scheiblin, Judd F, Hultquist, Schuyler B, van Engelenburg, Eric O, Freed
Publikováno v: J Virol
The HIV-1 envelope glycoprotein (Env) contains a long cytoplasmic tail harboring highly conserved motifs that direct Env trafficking and incorporation into virions and promote efficient virus spread. The cellular trafficking factor Rab11a family inte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::935a0308d8a5fd58649a4cf1b5e7caa2
https://pubmed.ncbi.nlm.nih.gov/36354340
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4
Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14+Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines
Autor: Huxley K. Hoffman, Rebekah S. Aguilar, Austin R. Clark, Nicholas S. Groves, Nairi Pezeshkian, Merissa M. Bruns, Schuyler B. van Engelenburg
Publikováno v: Journal of Virology. 96
HIV-1 envelope glycoprotein (Env) evades immune neutralization through many mechanisms. One immune evasion strategy may result from the internalization of excess surface-exposed Env to prevent antibody-dependent cellular cytotoxicity or neutralizatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8ed7514411f2e3b2316a5bfa2dd8ff
https://doi.org/10.1128/jvi.00767-22
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5
Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14
Autor: Huxley K, Hoffman, Rebekah S, Aguilar, Austin R, Clark, Nicholas S, Groves, Nairi, Pezeshkian, Merissa M, Bruns, Schuyler B, van Engelenburg
Publikováno v: Journal of virology. 96(14)
Production of infectious HIV-1 particles requires incorporation of the viral envelope glycoprotein (Env) at the plasma membrane (PM) of infected CD4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c405283b11b10c25a3ae8a2805af381a
https://pubmed.ncbi.nlm.nih.gov/35770989
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6
Rab14/MACF2 complex regulates endosomal targeting during cytokinesis
Autor: Paulius Gibieža, Rytis Prekeris, Schuyler Van Engeleburg, Huxley K. Hoffman, Eric Peterman, Vytenis Arvydas Skeberdis
Publikováno v: Molecular Biology of the Cell
Abscission is a complex cellular process that is required for mitotic division. It is well established that coordinated and localized changes in actin and microtubule dynamics are vital for cytokinetic ring formation, as well as establishment of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee8a218b3baa577fb423fd815c9a86b
https://doi.org/10.1091/mbc.e20-09-0607
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7
Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions
Autor: Huxley K. Hoffman, Schuyler B. van Engelenburg, Eric O. Freed, Melissa V. Fernandez, Nicholas S. Groves
Publikováno v: The Journal of Biological Chemistry
The endosomal sorting complexes required for transport (ESCRT) machinery drives membrane scission for diverse cellular functions that require budding away from the cytosol, including cell division and transmembrane receptor trafficking and degradatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047c3ce3f3603635f8540cc0a5960cb8
https://doi.org/10.1074/jbc.ra119.009372
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8
An open-access volume electron microscopy atlas of whole cells and tissues
Autor: Nirmala Iyer, Alex T. Ritter, Melanie Freeman, Michele Solimena, Andreas Müller, C. Shan Xu, H. Amalia Pasolli, Ira Mellman, Tobias C. Walther, Robert V. Farese, Aubrey V. Weigel, Jeeyun Chung, Shin-ya Takemura, Schuyler B. van Engelenburg, Huxley K. Hoffman, Song Pang, Jennifer Lippincott-Schwartz, Harald F. Hess, Gleb Shtengel, Zhiyuan Lu, Davis Bennett
Publikováno v: Nature
Nature 599, 147-151 (2021)
Understanding cellular architecture is essential for understanding biology. Electron microscopy (EM) uniquely visualizes cellular structures with nanometer resolution. However, traditional methods, such as thin-section EM or EM tomography, have limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b481f9c8a055fb8635d1d6af91512
https://pubmed.ncbi.nlm.nih.gov/34732896
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9
Elucidating the Basis for Permissivity of the MT-4 T-Cell Line to Replication of an HIV-1 Mutant Lacking the gp41 Cytoplasmic Tail
Autor: Melissa V. Fernandez, Eric O. Freed, Schuyler B. van Engelenburg, Nairi Pezeshkian, Huxley K. Hoffman, Philip R. Tedbury
Publikováno v: J Virol
HIV-1 encodes an envelope glycoprotein (Env) that contains a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virus particles and viral transmission. In most physiologically relevant cell types, the gp41 CT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4fb93a626d2c3f374febc503ca5426
https://europepmc.org/articles/PMC7654282/
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