Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Huw Tanner"'
Autor:
Yan Lou, Sharadha Subramanian, Yingyun Wang, Lifeng Wan, John Tellew, Laura Tandeske, Benjamin R. Taft, Kalyani Gampa, Jacob R. Haling, Gisele Nishiguchi, Lina Setti, Alice Rico, Sylvia Ma, Payman Amiri, Mallika Singh, Huw Tanner, Brent A. Appleton, Robert J. Aversa, Sepideh Vaziri, Shenlin Huang, Johanna M. Jansen, Anne Van Abbema, Jing Yuan, Vesselina G. Cooke, Hanne Merritt, Aaron Smith, Wenlin Shao, Valery Polyakov, Fei Feng, Savithri Ramurthy, Matthew Burger, Mulugeta Mamo, Lesley A. Mathews Griner, Vijay Sethuraman, Victoriano Tamez, Michael Patrick Dillon, Emma Lees, Ina Dix, Paul A. Barsanti, Richard Zang, Darrin Stuart, Mohammad Hekmat-Nejad
Publikováno v:
Journal of medicinal chemistry. 60(12)
RAS oncogenes have been implicated in30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cells. To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2623e531b4911ee04267b3f1e132c67
https://pubmed.ncbi.nlm.nih.gov/28557458
https://pubmed.ncbi.nlm.nih.gov/28557458
Publikováno v:
Organic Letters. 5:4819-4822
The synthesis of the C-1−C-28 ABCD fragment of spongistatin is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment to an AB spiroketal aldehyde unit forms the desired C1−C28 advanced intermediate. Other feat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71d4ab0f8055bb4fa3890475d749655
https://doi.org/10.1021/ol035849+
https://doi.org/10.1021/ol035849+
Autor:
Payman Amiri, Darrin Stuart, Giordano Caponigro, Gisele Nishiguchi, Yuji Mishina, Brent A. Appleton, Huw Tanner, Richard Zang, Wenlin Shao, Matthew Burger, Mallika Singh, John Tellew, Savithri Ramurthy, Valery Polyakov, Alice Rico, Vesselina G. Cooke, Mohammad Hekmat-Nejad, Yun Feng, Ben Taft, Lesley A. Mathews Griner
Publikováno v:
Cancer Research. 76:330-330
The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at multiple nodes in the pathway, the most prevalent of which are mutations in RAS or BRAF. While BRAFV60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abad7ed9cbdfcbf03e39f92bca3e56cb
https://doi.org/10.1158/1538-7445.am2016-330
https://doi.org/10.1158/1538-7445.am2016-330
Publikováno v:
ChemInform. 40
A new synthesis of 3,3′-bioxindoles is reported that is well suited for the preparation of unsymmetrical structures. In the key step, 3-hydroxy-3,3′-bioxindoles are constructed by Mukaiyama aldol reaction of 2-siloxyindoles with isatins These ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f51d7c57564f3f1bd4394af92b1ee9e
https://doi.org/10.1002/chin.200915115
https://doi.org/10.1002/chin.200915115
Publikováno v:
The Journal of organic chemistry. 73(22)
A new synthesis of 3,3′-bioxindoles is reported that is well suited for the preparation of unsymmetrical structures. In the key step, 3-hydroxy-3,3′-bioxindoles are constructed by Mukaiyama aldol reaction of 2-siloxyindoles with isatins These ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0675b086c31650ffce24c68ed988d2
https://pubmed.ncbi.nlm.nih.gov/18855482
https://pubmed.ncbi.nlm.nih.gov/18855482
Autor:
Alan S. Jessiman, Adam C. Talbot, David F. Hook, Huw Tanner, Paolo Orsini, Shigeo Yamanoi, Steven V. Ley, Alessandra Scolaro, Shigeru Kawahara, Matthew R. Ball, Matthew J. Gaunt
Publikováno v:
Angewandte Chemie (International ed. in English). 44(34)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79bfcd2983ceb9638d4e158d1bc69bf
https://pubmed.ncbi.nlm.nih.gov/16059947
https://pubmed.ncbi.nlm.nih.gov/16059947
Publikováno v:
ChemInform. 35
The synthesis of the C-1−C-28 ABCD fragment of spongistatin is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment to an AB spiroketal aldehyde unit forms the desired C1−C28 advanced intermediate. Other feat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6405a2b809d92eee498d774201d263
https://doi.org/10.1002/chin.200416189
https://doi.org/10.1002/chin.200416189
Publikováno v:
ChemInform. 35
A practical and efficient route to the CD spiroketal (C-16-C-28) of the spongistatins is reported. Two stereocenters are introduced from chiral building blocks with the remainder introduced by substrate-controlled transformations. The key beta-keto-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1f060960ef53eac5d48bc5b7360a74
https://doi.org/10.1002/chin.200416188
https://doi.org/10.1002/chin.200416188