Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Huw E L, Williams"'
Autor:
Samuel Furse, Adam J. Watkins, Nima Hojat, James Smith, Huw E. L. Williams, Davide Chiarugi, Albert Koulman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism. They use it to show that high paternal carbohydrate intake influences lipid metabolism in offspr
Externí odkaz:
https://doaj.org/article/69145bc415ce485fab5b9db61c31538e
Autor:
Cristina Padilla, Franck Quero, Marzena Pępczyńska, Paulo Díaz-Calderon, Juan Pablo Acevedo, Nicholas Byres, Jonny J. Blaker, William MacNaughtan, Huw E. L. Williams, Javier Enrione
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7489
For biomedical applications, gelatin is usually modified with methacryloyl groups to obtain gelatin methacryloyl (GelMA), which can be crosslinked by a radical reaction induced by low wavelength light to form mechanically stable hydrogels. The potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74fd76c1762627afa6ad37cb34ca625
http://hdl.handle.net/10852/102400
http://hdl.handle.net/10852/102400
Autor:
Alaa T. Al-sandaqchi, Victoria Marsh, Huw E. L. Williams, Carl W. Stevenson, Hany M. Elsheikha
Publikováno v:
Microorganisms, Vol 8, Iss 9, p 1386 (2020)
Toxoplasma gondii (T. gondii), the causative agent of toxoplasmosis, is a frequent cause of brain infection. Despite its known ability to invade the brain, there is still a dire need to better understand the mechanisms by which this parasite interact
Externí odkaz:
https://doaj.org/article/f0f2992c9f6f4e968e9c36d58cecefe6
Autor:
Samuel Furse, Laura C. Kusinski, Alison Ray, Coralie Glenn-Sansum, Huw E. L. Williams, Albert Koulman, Claire L. Meek
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11655
Peer reviewed: True
Funder: NIHR Cambridge BRC
Funder: core biochemical assay laboratory (CBAL)
Funder: core metabolomic and lipidomic laboratory (CMAL)
Male fertility, as manifest by the quantity and progressive motility of sperm
Funder: NIHR Cambridge BRC
Funder: core biochemical assay laboratory (CBAL)
Funder: core metabolomic and lipidomic laboratory (CMAL)
Male fertility, as manifest by the quantity and progressive motility of sperm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c08ee67d738f5c8b71cba5fc76237c
Autor:
Samuel Furse, Adam J. Watkins, Samuel Virtue, Antonio Vidal-Puig, Risha Amarsi, Huw E. L. Williams, Marika Charalambous, Albert Koulman
Publikováno v:
Analytical and Bioanalytical Chemistry
Detailed molecular analysis is of increasing importance in research into the regulation of biochemical pathways, organismal growth and disease. Lipidomics in particular is increasingly sought after as it provides insight into molecular species involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7eba0fc0ea657876ba63ca7d02159f
https://doi.org/10.1007/s00216-021-03430-4
https://doi.org/10.1007/s00216-021-03430-4
Autor:
Rhys C. Griffiths, Huw E. L. Williams, Nick Mitchell, Jed Long, Frances R. Smith, Robert Layfield
Publikováno v:
Angewandte Chemie (International Ed. in English)
The development of site‐selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilitate the development of polypeptide conjugates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82209a4896142145546a7e41a28e2f6
https://doi.org/10.1002/ange.202006260
https://doi.org/10.1002/ange.202006260
Autor:
Alex Slater, Mark S. Searle, Lukasz Ciszewski, Linda Popplewell, Ngoc Lu-Nguyen, Andrew Brennan, Huw E. L. Williams, George Dickson
Publikováno v:
Nucleic Acids Research
Abnormal DUX4 expression in skeletal muscles plays a key role in facioscapulohumeral muscular dystrophy (FSHD) pathogenesis, although the molecular mechanisms regulating DUX4 expression are not fully defined. Using bioinformatic analysis of the genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd457d1c64fccb340bb47c560845c53
https://doi.org/10.1093/nar/gkaa146
https://doi.org/10.1093/nar/gkaa146
Autor:
Jed Long, Frances R. Smith, Nick Mitchell, Huw E. L. Williams, Daniel Scott, Rhys C. Griffiths, Robert Layfield, Neil J. Oldham
Publikováno v:
Angewandte Chemie. 134
Post-translational modifications (PTMs) enhance the repertoire of protein function and mediate or influence the activity of the majority of cellular processes. The preparation of site-specifically and homogeneously modified proteins to apply as tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28aebb0286bbfaf5de09f57d7f5e7297
https://doi.org/10.1002/ange.202110223
https://doi.org/10.1002/ange.202110223
Autor:
Rhys C, Griffiths, Frances R, Smith, Jed E, Long, Daniel, Scott, Huw E L, Williams, Neil J, Oldham, Robert, Layfield, Nicholas J, Mitchell
Publikováno v:
Angewandte Chemie (International ed. in English). 61(2)
Post-translational modifications (PTMs) enhance the repertoire of protein function and mediate or influence the activity of many cellular processes. The preparation of site-specifically and homogeneously modified proteins, to apply as tools to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfe82b0b435d7af0e23969c7fe6e0597
https://pubmed.ncbi.nlm.nih.gov/34713958
https://pubmed.ncbi.nlm.nih.gov/34713958
Autor:
Huw E. L. Williams, Caroline Armstrong, Simon G. Caulton, José A. López, Szu S. Wong, Juliet Morgan, Ruiqi Ng, Muhammad Saleem, Jonas Emsley, Alice Fickling, Mark S. Searle, Adam D. Munday
Publikováno v:
'Blood Advances ', vol: 3, pages: 1450-1459 (2019)
Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, αMβ2, CD11b/CD18) and platelet glycoprotein Ibα (GPIbα) are critical to vascular inflammation. To define the key residues at the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41749711f9a9e4479628f75d0ca7072c
https://doi.org/10.1182/bloodadvances.2018027011
https://doi.org/10.1182/bloodadvances.2018027011