Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Huw D, Summers"'
Autor:
John W. Wills, Jack Robertson, Pani Tourlomousis, Clare M.C. Gillis, Claire M. Barnes, Michelle Miniter, Rachel E. Hewitt, Clare E. Bryant, Huw D. Summers, Jonathan J. Powell, Paul Rees
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100398- (2023)
Summary: Unlocking and quantifying fundamental biological processes through tissue microscopy requires accurate, in situ segmentation of all cells imaged. Currently, achieving this is complex and requires exogenous fluorescent labels that occupy sign
Externí odkaz:
https://doaj.org/article/50b76a76164d464598c69dcfa77226e2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Cellular uptake of nanoparticles is highly variable between individual cells in a population. Here, the authors show that this heterogeneity is a result of varying numbers of nanoparticle-containing endosomes while the nanoparticle dose per endosome
Externí odkaz:
https://doaj.org/article/229f11f983af4f06a83137aaba5539e2
Autor:
Huw D. Summers, Carla P. Gomes, Aida Varela-Moreira, Ana P. Spencer, Maria Gomez-Lazaro, Ana P. Pêgo, Paul Rees
Publikováno v:
Nanomaterials, Vol 11, Iss 10, p 2606 (2021)
Nanoparticle drug delivery vehicles introduce multiple pharmacokinetic processes, with the delivery, accumulation, and stability of the therapeutic molecule influenced by nanoscale processes. Therefore, considering the complexity of the multiple inte
Externí odkaz:
https://doaj.org/article/330175154cfa481caeaf369fe0074dc9
Autor:
Thomas Blasi, Holger Hennig, Huw D. Summers, Fabian J. Theis, Joana Cerveira, James O. Patterson, Derek Davies, Andrew Filby, Anne E. Carpenter, Paul Rees
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Imaging flow cytometry enables high-throughput acquisition of fluorescence, brightfield and darkfield images of biological cells. Here, Blasi et al.demonstrate that applying machine learning algorithms on brightfield and darkfield images can detect c
Externí odkaz:
https://doaj.org/article/64eccd9285fd45858c93a445b1345a3c
Autor:
Cain Craig Truman Clark, Claire Marie Barnes, Huw D Summers, Kelly Mackintosh, Gareth Stratton
Publikováno v:
European Journal of Human Movement, Vol 39 (2018)
Introduction. Frequency spectrum characteristics derived from raw accelerometry, such as spectral purity, have the potential to reveal detailed information about children’s movement quality, but remain unexplored in children’s physical activity.
Externí odkaz:
https://doaj.org/article/e29e68908f7c42498a89f9efde9027bd
Publikováno v:
Cell reports methods. 2(11)
Automated microscopy and computational image analysis has transformed cell biology, providing quantitative, spatially resolved information on cells and their constituent molecules from the sub-micron to the whole-organ scale. Here we explore the appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2937cc3b0dee9a5edd29c76f584b3a3f
https://pubmed.ncbi.nlm.nih.gov/36452868
https://pubmed.ncbi.nlm.nih.gov/36452868
Autor:
John W. Wills, Ruby Buckley, Catherine A. Thornton, Claire M. Barnes, Paul Rees, George E. Johnson, Julia Kenny, Rachel E. Hewitt, Danielle S.G. Harte, Anne E. Carpenter, James G. Cronin, Minh Doan, Huw D. Summers, Andrew Filby, Benjamin J. Rees, Rachel E. Barnes, Jatin R. Verma, Qiellor Haxhiraj, Matthew A. Rodrigues, Anthony M. Lynch
Publikováno v:
Archives of Toxicology
The in vitro micronucleus assay is a globally significant method for DNA damage quantification used for regulatory compound safety testing in addition to inter-individual monitoring of environmental, lifestyle and occupational factors. However, it re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f8413ddfcd3455a7d89fcc779c1196
https://doi.org/10.1007/s00204-021-03113-0
https://doi.org/10.1007/s00204-021-03113-0
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263846 (2022)
External peak power in the countermovement jump is frequently used to monitor athlete training. The gold standard method uses force platforms, but they are unsuitable for field-based testing. However, alternatives based on jump flight time or Newtoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e3a9bf62463e99c8ff3f89261c8717
https://cronfa.swan.ac.uk/Record/cronfa59326/Download/59326__22355__00ce67b96c0e4d948043e611686b1b3f.pdf
https://cronfa.swan.ac.uk/Record/cronfa59326/Download/59326__22355__00ce67b96c0e4d948043e611686b1b3f.pdf
Publikováno v:
Cytometry
Eosinophils are granular leukocytes that play a role in mediating inflammatory responses linked to infection and allergic disease. Their activation during an immune response triggers spatial reorganization and eventual cargo release from intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc5b04ab0ca9dd09f88edac97781724
https://doi.org/10.1002/cyto.a.23884
https://doi.org/10.1002/cyto.a.23884