Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Huw B. Jones"'
Autor:
Jonathan Wills, Ian D. Wilson, Alan McCarthy, Huw B. Jones, Chris Page, Kerry Ratcliffe, Sunil Sarda, Tim Schulz-Utermoehl, Kathryn Pickup, Alison V. M. Rodrigues, Elizabeth A. Partridge, Scott W. Martin
Publikováno v:
Archives of Toxicology. 91:2643-2653
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed dis
Autor:
Kassiani Kalaitzi, Alison J. Foster, James E. Sidaway, Brian G. Lake, Terry C. Orton, Huw B. Jones
Publikováno v:
Toxicology. 430:152343
In this study liver tumours produced in male and female mice of the low spontaneous liver tumour incidence C57BL/10J strain treated for 99 weeks with 1000 ppm in the diet with the model constitutive androstane receptor (CAR) activator sodium phenobar
Autor:
Catherine Gardner-Thorpe, Huw B Jones, C.J. Lloyd, Takaaki Sato, Victoria King, David Houghton, Antonio Gagliardi-Lugo
Publikováno v:
British Journal of Oral and Maxillofacial Surgery. 57:e39
Publikováno v:
Toxicologic Pathology. 42:1250-1266
Pharmaceutical therapies for non-insulin-dependent diabetes mellitus (NIDDM) include plasma glucose lowering by enhancing glucose utilization. The mitochondrial pyruvate dehydrogenase (PDH) complex is important in controlling the balance between gluc
Autor:
Jaimini Reens, Huw B. Jones, Derrick Morgan, David M. Smith, Sue Bickerton, Catherine J. Betts, Richard P. Jenkins, Alison L. Bigley, Simon Brocklehurst, Nicky Whalley
Publikováno v:
International Journal of Experimental Pathology. 95:29-48
Antagonism of the effects of glucagon as an adjunct therapy with other glucose-lowering drugs in the chronic treatment of diabetes has been suggested to aggressively control blood glucose levels. Antagonism of glucagon effects, by targeting glucagon
Autor:
Huw B. Jones, Ian D. Wilson, Alison J. Foster, James A. Akingbasote, J. Gerry Kenna, Rhiannon David, Nigel J. Gooderham
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit no functional expression of hepatic cytochrome P450 (P450) when compared to wild type (WT) mice, but have normal hepatic and extrahepatic expression of other biotransformation en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad67f203607eb0b677879b19d0a847b
https://europepmc.org/articles/PMC6062145/
https://europepmc.org/articles/PMC6062145/
Autor:
Kathryn, Pickup, Scott, Martin, Elizabeth A, Partridge, Huw B, Jones, Jonathan, Wills, Tim, Schulz-Utermoehl, Alan, McCarthy, Alison, Rodrigues, Chris, Page, Kerry, Ratcliffe, Sunil, Sarda, Ian D, Wilson
Publikováno v:
Archives of Toxicology
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed dis
Autor:
Huw B. Jones, Sunil Sarda, Jonathan Wills, Scott W. Martin, Kathryn Pickup, Alison V. M. Rodrigues, Ian D. Wilson, Chris Page
Publikováno v:
Xenobiotica. 44:164-173
1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single oral dose of 10 mg/kg to hepatic reductase null (HRN) mice. 2. The majority of the [(14)C]-fenclozic acid was eliminated via the uri
Publikováno v:
Toxicologic Pathology. 42:591-602
In recent years, there has been considerable activity to identify urinary biomarkers of nephrotoxicity as noninvasive measurements with greater sensitivity and specificity than traditional biomarkers, such as serum creatinine and blood urea nitrogen.
Autor:
J.L. Ulloa, John C. Waterton, J. Gerry Kenna, James W.T. Yates, Simone H. Stahl, Paul D. Hockings, Neil Woodhouse, Huw B. Jones
Publikováno v:
Nmr in Biomedicine
Drug-induced liver injury (DILI) is a clinically important adverse drug reaction, which prevents the development of many otherwise safe and effective new drugs. Currently, there is a lack of sensitive and specific biomarkers that can be used to predi