Harmonization status of procalcitonin measurements: what do comparison studies and EQA schemes tell us?

Autor: Gareth J Davies, Vincent Delatour, Gunnar Nordin, Joëlle Vinh, Bernard Poggi, Amandine Bœuf, Ulla Tiikkainen, Philipp Schuetz, Patricia Kaiser, Marc H M Thelen, Jens Pfannkuche, Dagmar Kesseler, Huu-Hien Huynh, Eline A E van der Hagen, Mario Plebani, Tony Badrick, Anja Kessler

Publikováno v: Clinical Chemistry and Laboratory Medicine
Clinical Chemistry and Laboratory Medicine, De Gruyter, 2021, 59 (10), pp.1610-1622. ⟨10.1515/cclm-2021-0566⟩

Sepsis represents a global health priority because of its high mortality and morbidity. The key to improving prognosis remains an early diagnosis to initiate appropriate antibiotic treatment. Procalcitonin (PCT) is a recognized biomarker for the earl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6af21029ed673d384d0663226d65f8
https://doi.org/10.1515/cclm-2021-0566

Candidate high-resolution mass spectrometry-based reference method for the quantification of procalcitonin in human serum using a characterized recombinant protein as a primary calibrator

Autor: Huu-Hien Huynh, Vincent Delatour, Maxence Derbez-Morin, Qinde Liu, Amandine Boeuf, Joëlle Vinh

Publikováno v: Analytical Chemistry
Analytical Chemistry, 2022, 94 (10), pp.4146-4154. ⟨10.1021/acs.analchem.1c03061⟩

International audience; Procalcitonin (PCT) is a widely used biomarker for rapid sepsis diagnosis and antibiotic stewardship. Variability of results in commercial assays has highlighted the need for standardization of PCT measurements. An antibody-fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9911c81e069e1126d9ab66d8f06975
https://hal.science/hal-03616503

Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration

Autor: Joëlle Vinh, Anne-Marie Dupuy, Huu-Hien Huynh, Béatrice Lalere, Vincent Delatour, Maxence Derbez-Morin, Amandine Bœuf

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 2021, 413 (19), pp.4707-4725. ⟨10.1007/s00216-021-03361-0⟩
Analytical and Bioanalytical Chemistry, Springer Verlag, 2021, 413 (19), pp.4707-4725. ⟨10.1007/s00216-021-03361-0⟩

The quantification of low abundant proteins in complex matrices by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) remains challenging. A measurement procedure based on optimized antibody-free sample preparation and isotope dilut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c430573347c2f0da7c22242710323453
https://hal.science/hal-03335220

Evaluation of the necessity and the feasibility of the standardization of procalcitonin measurements: Activities of IFCC WG-PCT with involvement of all stakeholders

Autor: Huu-Hien Huynh, Amandine Bœuf, Joëlle Vinh, Vincent Delatour, Qinde Liu, Yizhao Chen, Klaus Schneider, Patricia Kaiser, Pierre Hausfater, Philippe Schütz, Christos Tsatsanis, Annie Dupuy, Stefano Pastori, Jens Pfannkuche, Chong Yuan, Birger Machetanz, Michael Rottmann, Andrew Rybin, Neil Parker, Jutta Odarjuk, Barbara Thomas, Michelle Solari, Kim Paulsen, Scott Ruetten, Lauren Seaver, Helene Briand, Carole Tourneur, Luca Pallavicini, Nadia Corocher, Godwin Ogbonna, Maria Patru, Philip Bryan, Sameh Zion, Matthias Grimmler, Thomas Masetto, Piitu Jauria

Publikováno v: Clinica Chimica Acta
Clinica Chimica Acta, Elsevier, 2021, 515, pp.111-121. ⟨10.1016/j.cca.2021.01.004⟩

Procalcitonin (PCT) is an important biomarker for sepsis diagnosis and management. To date, there is no higher-order reference measurement procedure (RMP) and certified reference material to achieve global standardization of results and results trace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75ebadbffdb04b78e9e3c6bd5e750ab
https://hal.archives-ouvertes.fr/hal-03150436/document

Development and Validation of a Simultaneous Quantification Method of Ruxolitinib, Vismodegib, Olaparib, and Pazopanib in Human Plasma Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

Autor: Claire Pressiat, Isabelle Madelaine, Cécile Chougnet, L. Goldwirt, Hélène Sauvageon, Samia Mourah, Christine Le Maignan, Alain Plé, Huu-Hien Huynh

Publikováno v: Therapeutic Drug Monitoring. 40:337-343

Background A simple, rapid, and sensitive liquid chromatography coupled with tandem mass spectrometry method has been developed and validated for the quantification of ruxolitinib, olaparib, vismodegib, and pazopanib in human plasma. Methods After a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc0feb2ac0a1813fe9baa84a202ad1f
https://doi.org/10.1097/ftd.0000000000000497