Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations.

Autor: Rebbeck TR; Harvard TH Chan School of Public Health and Dana Farber Cancer Institute, Boston, USA., Friebel TM; Harvard TH Chan School of Public Health and Dana Farber Cancer Institute, Boston, USA., Friedman E; The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Huo D; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, USA., Kwong A; The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China., Olah E; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Olopade OI; Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, USA., Solano AR; INBIOMED, Faculty of Medicine, University of Buenos Aires/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, Buenos Aires, Argentina., Teo SH; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Weitzel JN; Division of Clinical Cancer Genomics, City of Hope Cancer Center, California, USA., Chan TL; Division of Molecular Pathology, Department of Pathology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong., Couch FJ; Department of Laboratory Medicine and Pathology, and Health Sciences Research, Rochester, USA., Goldgar DE; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, USA., Kruse TA; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Palmero EI; Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil., Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.; Cancer Research Center, Seoul National University, Seoul, Korea., Torres D; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Human Genetics, Pontificia Universidad Javeriana, Colombia., van Rensburg EJ; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa., McGuffog L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Parsons MT; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Leslie G; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Aalfs CM; Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands., Abugattas J; City of Hope Clinical Cancer Genomics Community Research Network, Duarte, USA., Adlard J; Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK., Agata S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Aittomäki K; Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland., Andrews L; Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, Australia., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Arason A; Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Arnold N; Department of Gynaecology & Oncology, Medical University of Vienna, Austria., Arun BK; Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, Houston, USA., Asseryanis E; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Auerbach L; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Azzollini J; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT), Milan, Italy., Balmaña J; Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain., Barile M; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Barkardottir RB; Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Barrowdale D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Benitez J; Human Genetics Group and Genotyping Unit (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Berger A; Dept of OB/GYN, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Berger R; The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel., Blanco AM; UCSF Cancer Genetics and Prevention Program, San Francisco, USA., Blazer KR; Division of Clinical Cancer Genomics, City of Hope Cancer Center, California, USA., Blok MJ; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Bonadona V; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon, France., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Bradbury AR; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Brewer C; Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK., Buecher B; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Buys SS; Department of Medicine, Huntsman Cancer Institute, Salt Lake City, USA., Caldes T; Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Caliebe A; Institute of Human Genetics, University Hospital of Schleswig-Holstein, Kiel, Germany., Caligo MA; Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy., Campbell I; Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia., Caputo SM; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Chiquette J; CRCHU de Quebec-oncologie, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Sainte-Foy, Canada., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, USA., Claes KBM; Center for Medical Genetics, Ghent University, Gent, Belgium., Collée JM; Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands., Cook J; Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK., Davidson R; Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK., de la Hoya M; Molecular Oncology Laboratory, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., De Leeneer K; Center for Medical Genetics, Ghent University, Gent, Belgium., de Pauw A; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Delnatte C; Unité d'oncogénétique, ICO-Centre René Gauducheau, Saint Herblain, France., Diez O; Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Barcelona, Spain., Ding YC; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, USA., Ditsch N; Department of Gynaecology and Obstetrics, Ludwig-Maximilian University, Munich, Germany., Domchek SM; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Dorfling CM; Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, South Africa., Velazquez C; Cáncer Hereditario, Instituto de Biología y Genética Molecular, IBGM, Universidad de Valladolid, Valladolid, Spain., Dworniczak B; Institute of Human Genetics, University of Münster, Münster, Germany., Eason J; Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Eeles R; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK., Ehrencrona H; Department of Clinical Genetics, Lund University Hospital, Lund, Sweden., Ejlertsen B; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Engert S; Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University, Munich, Germany., Evans DG; Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Sciences, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Faivre L; Centre de Lutte Contre le Cancer Georges François Leclerc, France and Genomic and Immunotherapy Medical Institute, Dijon University Hospital, Dijon, France., Feliubadaló L; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology-Bellvitge Biomedical Research Institute), Barcelona, Spain., Ferrer SF; Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France., Foretova L; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Fowler J; Columbus Cancer Council, Ohio State University, Columbus, USA., Frost D; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Galvão HCR; Oncogenetics Department, Barretos Cancer Hospital, Barretos, Brazil., Ganz PA; UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, USA., Garber J; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, USA., Gauthier-Villars M; Service de Génétique, Institut Curie, 26 rue d'Ulm, Paris, France., Gehrig A; Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Germany, Würzburg., Gerdes AM; Department of Clinical Genetics, Copenhagen, Denmark., Gesta P; Service Régional Oncogénétique Poitou-Charentes, Centre Hospitalier, Niort, France., Giannini G; Department of Molecular Medicine, University La Sapienza, and Istituto Pasteur - Fondazione Cenci-Bolognetti, Rome, Italy., Giraud S; Bâtiment Cheney D, Centre Léon Bérard, Lyon, France., Glendon G; Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA., Greene MH; Clinical Genetics Branch, DCEG, NCI, NIH, Bethesda, USA., Gronwald J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Gutierrez-Barrera A; Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, Houston, USA., Hahnen E; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Hauke J; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Henderson A; Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK., Hentschel J; Institute of Human Genetics, University Leipzig, Leipzig, Germany., Hogervorst FBL; Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands., Honisch E; Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University, Düsseldorf, Germany., Imyanitov EN; N.N. Petrov Institute of Oncology, St. Petersburg, Russia., Isaacs C; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, USA., Izatt L; Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Izquierdo A; Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., James P; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia., Janavicius R; Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark., John EM; Department of Epidemiology, Cancer Prevention Institute of California, Fremont, USA.; Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA., Vijai J; Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA., Kaczmarek K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA., Kast K; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany., Investigators K; Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia and The Sir Peter MacCallum Department of Oncology University of Melbourne, Parkville, Australia., Kim SW; Department of Surgery, Daerim St. Mary's Hospital, Seoul, Korea., Konstantopoulou I; Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Athens, Greece., Korach J; The Gyneco-Oncology Department, Chaim Sheba Medical Center, Ramat Gan, Israel., Laitman Y; The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Lasa A; Servicio de Genética-CIBERER U705, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Lasset C; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, 28 rue Laënnec, Lyon, France., Lázaro C; Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology-Bellvitge Biomedical Research Institute), Barcelona, Spain., Lee A; The Feinstein Institute for Medical Research, Manhasset, USA., Lee MH; Department of Surgery, Soonchunhyang University and Seoul Hospital, Seoul, Korea., Lester J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA., Lesueur F; Inserm U900, Institut Curie, PSL Research University, Paris, France., Liljegren A; Department of Oncology Radiumhemmet and Institution of Oncology and Patology, Karolinska University Hospital and Karolinska Institutet, Solna, Sweden., Lindor NM; Department of Health Sciences Research, Mayo Clinic, Scottsdale, USA., Longy M; Oncogénétique, Institut Bergonié, Bordeaux, France., Loud JT; Clinical Genetics Branch, DCEG, NCI, NIH, Bethesda, USA., Lu KH; Department of Gynecological Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, Houston, USA., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Machackova E; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Manoukian S; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT), Milan, Italy., Mari V; Centre Antoine Lacassagne, Nice, France., Martínez-Bouzas C; Laboratorio de Genética Molecular, Servicio de Genética, Hospital Universitario Cruces, BioCruces Health Research Institute, Barakaldo, Spain., Matrai Z; Department of Surgery, National Institute of Oncology, Budapest, Hungary., Mebirouk N; Inserm U900, Institut Curie, PSL Research University, Paris, France., Meijers-Heijboer HEJ; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands., Meindl A; Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University, Munich, Germany., Mensenkamp AR; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Mickys U; Vilnius university Santariskiu hospital, National Center of Pathology, Vilnius, Lithuania., Miller A; NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, USA., Montagna M; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Moysich KB; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, USA., Mulligan AM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada., Musinsky J; Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, USA., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, HUS, Finland., Ngeow J; Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Bukit Merah, Singapore., Nguyen HP; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany., Niederacher D; Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University, Düsseldorf, Germany., Nielsen HR; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Nielsen FC; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Nussbaum RL; Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, USA., Offit K; Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, USA., Öfverholm A; Department of Clinical Genetics, Sahlgrenska University Hospital, Gothenburg, Sweden., Ong KR; West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, UK., Osorio A; Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Papi L; Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy., Papp J; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary., Pasini B; Department of Medical Sciences, University of Turin, Turin, Italy., Pedersen IS; Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark., Peixoto A; Department of Genetics, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Peruga N; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Peterlongo P; IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy., Pohl E; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Pradhan N; Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA., Prajzendanc K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Prieur F; Service de Génétique Clinique Chromosomique et Moléculaire, Hôpital Nord, St Etienne, France., Pujol P; Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale Tumori (INT), Milan, Italy., Ramus SJ; School of Women's and Children's Health, UNSW, Sydney, Australia.; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia., Rantala J; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Rashid MU; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan., Rhiem K; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Robson M; Clinical Genetics Services, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA., Rodriguez GC; Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, USA., Rogers MT; All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK., Rudaitis V; Department of Gynecology, Vilnius University Hospital Santariskiu Clinics, Centre of Woman's Health and pathology, Vilnius, Lithuania., Schmidt AY; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Schmutzler RK; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Senter L; Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, USA., Shah PD; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA., Sharma P; Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, USA., Side LE; North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada., Singer CF; Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Skytte AB; Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark., Slavin TP; Division of Clinical Cancer Genomics, City of Hope Cancer Center, California, USA., Snape K; Medical Genetics Unit, University of London, St George's, UK., Sobol H; Département Oncologie Génétique, Prévention et Dépistage, Institut Paoli-Calmettes, Marseille Medical School-AM University, Marseille, France., Southey M; Département Oncologie Génétique, Prévention et Dépistage, Institut Paoli-Calmettes, Marseille Medical School-AM University, Marseille, France.; Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia., Steele L; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, USA., Steinemann D; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany., Sukiennicki G; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Sutter C; Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany., Szabo CI; National Human Genome Research Institute, National Institutes of Health, Bethesda, USA., Tan YY; Dept of OB/GYN, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Teixeira MR; Department of Genetics, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal., Terry MB; Department of Epidemiology, Columbia University, New York, USA., Teulé A; Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Gran Via de l'Hospitalet, Barcelona, Spain., Thomas A; Department of Health Sciences Research, Mayo Clinic, Rochester, USA., Thull DL; Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, USA., Tischkowitz M; Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Canada., Tognazzo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Toland AE; Division of Human Genetics, Departments of Internal Medicine and Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, USA., Topka S; Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA., Trainer AH; Parkville Familial Cancer Centre, Royal Melbourne Hospital, Melbourne, Australia., Tung N; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Massachusetts, USA., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., van der Hout AH; Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands., van der Kolk LE; Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Luijt RB; Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands., Van Heetvelde M; Center for Medical Genetics, Ghent University, Gent, Belgium., Varesco L; Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy., Varon-Mateeva R; Institute of Human Genetics, Campus Virchov Klinikum, Berlin, Germany., Vega A; Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain., Villarreal-Garza C; Departamento de Investigacion y de Tumores Mamarios del, Instituto Nacional de Cancerologia, Mexico City, Mexico.; Centro de Cancer de Mama del Hospital Zambrano Hellion, Tecnologico de Monterrey, San Pedro Garza Garcia, Mexico., von Wachenfeldt A; Department of Oncology, Karolinska University Hospital, Stockholm, Sweden., Walker L; Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK., Wang-Gohrke S; Department of Gynaecology and Obstetrics, University Hospital, Ulm, Germany., Wappenschmidt B; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany., Weber BHF; Institute of Human Genetics, Regensburg University, Regensburg, Germany., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Athens, Greece., Yoon SY; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia., Zanzottera C; Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT), Milan, Italy., Zidan J; Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel., Zorn KK; Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, USA., Hutten Selkirk CG; Center for Medical Genetics, North Shore University Health System, Evanston, USA., Hulick PJ; Medical Director, Center for Medical Genetics, NorthShore University HealthSystem, Clinical Assistant Professor of Medicine, University of Chicago Pritzker School of Medicine, Evanston, USA., Chenevix-Trench G; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Spurdle AB; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Nathanson KL; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.

Publikováno v: Human mutation [Hum Mutat] 2018 May; Vol. 39 (5), pp. 593-620. Date of Electronic Publication: 2018 Mar 12.

Primary care physician experiences with integrated pharmacogenomic testing in a community health system.

Autor: Lemke AA; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Hutten Selkirk CG; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Glaser NS; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Sereika AW; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Wake DT; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Hulick PJ; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA., Dunnenberger HM; Center for Personalized Medicine, NorthShore University HealthSystem, 1001 University Place, Suite 160, Evanston, IL 60201, USA.

Publikováno v: Personalized medicine [Per Med] 2017 Sep; Vol. 14 (5), pp. 389-400. Date of Electronic Publication: 2017 Aug 02.