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Tackling assay interference associated with small molecules.

Autor: Tan L; Drug Discovery Sciences, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria., Hirte S; Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna, Austria., Palmacci V; Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna, Austria., Stork C; Department of Informatics, Center for Bioinformatics, Faculty of Mathematics, Informatics and Natural Sciences, Universität Hamburg, Hamburg, Germany.; BASF SE, Ludwigshafen am Rhein, Germany., Kirchmair J; Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria. johannes.kirchmair@univie.ac.at.; Christian Doppler Laboratory for Molecular Informatics in the Biosciences, Department for Pharmaceutical Sciences, University of Vienna, Vienna, Austria. johannes.kirchmair@univie.ac.at.

Publikováno v: Nature reviews. Chemistry [Nat Rev Chem] 2024 May; Vol. 8 (5), pp. 319-339. Date of Electronic Publication: 2024 Apr 15.

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Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy.

Autor: Rejnowicz, Ewa, Batchelor, Matthew, Leen, Eoin, Ahangar, Mohd Syed, Burgess, Selena G., Richards, Mark W., Kalverda, Arnout P., Bayliss, Richard

Publikováno v: Biochemical Journal; Nov2024, Vol. 481 Issue 21, p1535-1556, 22p

NMR-Driven Discovery of Benzoylanthranilic Acid Inhibitors of Far Upstream Element Binding Protein Binding to the Human Oncogene c-myc Promoter

Autor: Huth, J. R., Yu, L., Collins, I., Mack, J., Mendoza, R., Isaac, B., Braddock, D. T., Muchmore, S. W., Comess, K. M., Fesik, S. W., Clore, G. M., Levens, D., Hajduk, P. J.

Publikováno v: Journal of Medicinal Chemistry; September 2004, Vol. 47 Issue: 20 p4851-4857, 7p