Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hutchison Alan J"'
Autor:
Barrington, William W., Jacobson, Kenneth A., Hutchison, Alan J., Williams, Michael, Stiles, Gary L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1989 Sep 01. 86(17), 6572-6576.
Externí odkaz:
https://www.jstor.org/stable/34575
Autor:
Waters, Stephen M. ‡, 1, Brodbeck, Robbin M. ‡, Steflik, Jeremy ‡, Yu, Jianying ‡, Baltazar, Carolyn ‡, Peck, Amy E. ‡, Severance, Daniel §, Zhang, Lu Yan ¶, Currie, Kevin ¶, Chenard, Bertrand L. ¶, Hutchison, Alan J. ¶, Maynard, George ¶, Krause, James E. ‡
Publikováno v:
In Journal of Biological Chemistry 9 December 2005 280(49):40617-40623
Autor:
Jayaraman Chandrasekhar, Raymond F. Horvath, Ping Ge, Stéphane De Lombaert, Hutchison Alan J, Kevin J. Hodgetts, Dario Doller, Robbin Brodbeck, James E. Krause, Diane Hoffman, Michael Gulianello, Yoon Taeyoung, John H. Kehne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4486-4490
The design, synthesis and structure-activity relationship studies of a novel series of CRF-1 receptor antagonists, the 2-arylpyrimidines, are described. The effects of substitution on the aromatic ring and the pyrimidine core on CRF-1 receptor bindin
Autor:
Frank Burkamp, Kevin J. Hodgetts, Rajagopal Bakthavatchalam, Robert Clarkson, Hutchison Alan J, Stéphane De Lombaert, Daniel N. Cortright, A. Brian Jones, Charles A. Blum, Peter Blurton, Harry Brielmann, Xiaozhang Zheng, Jayaraman Chandrasekhar, Marci Crandall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5217-5221
Bioisosteric replacement of piperazine with an aryl ring in lead VR1 antagonist 1 led to the biarylamide series. The development of B-ring SAR led to the conformationally constrained analog 70. The resulting aminoquinazoline 70 represents a novel VR1
Autor:
Hutchison Alan J, Kover Renata X, Robbin Brodbeck, Xiao-Shu He, Andrew Thurkauf, Kevin J. Hodgetts, Andrzej Kieltyka, Stanislaw Rachwal, Xiaoyan Zhang, John R. Peterson, Jan W. F. Wasley, Renee J. Primus, He Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3105-3109
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,
Autor:
Daniel Broom, David J. Wustrow, Bertrand L. Chenard, Hutchison Alan J, James E. Krause, David C. Ihle, Daniel N. Cortright, Yao Peng, Dawn Alderman, Charles S. Cheng, Kevin J. Hodgetts, Jayaraman Chandrasekhar, Jean Simmermacher-Mayer, Mark T. Kershaw, Qin Guo
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(18)
The design, synthesis, and structure-activity studies of a novel series of BK B 1 receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaq
Autor:
Xi Chen, Hilary Donovan, Andrew Thurkauf, Hutchison Alan J, Jan W. F. Wasley, Kristine Woodruff, Xiao Shu He, Robin Meade, Jun Yuan, Deborah K. Jones-Hertzog, Diane C. Hoffman
Publikováno v:
Journal of Medicinal Chemistry. 40:1-3
Autor:
Robbin Brodbeck, Carolyn Baltazar, Jianying Yu, Bertrand L. Chenard, Kevin P. M. Currie, Lu Yan Zhang, Hutchison Alan J, James E. Krause, Amy E. Peck, Daniel Severance, Stephen M. Waters, George D. Maynard, Jeremy Steflik
Publikováno v:
The Journal of biological chemistry. 280(49)
Anaphylatoxin C5a is a potent inflammatory mediator associated with pathogenesis and progression of several inflammation-associated disorders. Small molecule C5a receptor (C5aR) antagonist development is hampered by species-specific receptor biology
Autor:
James E. Krause, Hutchison Alan J
Publisher Summary In host defense, the complement system of blood-borne proteins initiates a series of cellular and inflammatory responses to divergent stimuli. Excessive activation of the complement system in man results in elevated C5a, a glycosyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c3e1e3d51f2408a5016ffc1625694b
https://doi.org/10.1016/s0065-7743(04)39011-1
https://doi.org/10.1016/s0065-7743(04)39011-1
Autor:
John F. Tallman, Geoff White, Matt Crago, Lu Marshall, James V. Cassella, Pamela Albaugh, James Gregory, Dorothy W. Gallagher, Hutchison Alan J, Phil C. Ross
Publikováno v:
Journal of medicinal chemistry. 45(23)
Benzodiazepines are allosteric modulators of the GABA(A) receptor. The traditionally prescribed benzodiazepines are nonselective and suffer from numerous side effects. Upon the identification of receptor subtypes, we set out to discover selective age