Electronic supplementary figures and figure legends from Targeting endogenous proteins for degradation through the affinity-directed protein missile system

Autor: Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, SAPKOTA, Gopal P.

Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches necessitate prolong

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Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Autor: Hutchinson, Luke D, Darling, Nicola J, Stephanos Nicolaou, Gori, Ilaria, Squair, Daniel R, Cohen, Philip, Hill, Caroline S, Sapkota, Gopal P

The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis

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Generation of Endogenous BMP Transcriptional Reporter Cells Through CRISPR/Cas9 Genome Editing.

Autor: Hutchinson LD; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK., Bozatzi P; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK., Macartney T; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK., Sapkota GP; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK. G.Sapkota@dundee.ac.uk.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1891, pp. 29-35.