Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events

Autor: Shim, Juyoung, Kennedy, Rachel H., Weatherly, Lisa M., Hutchinson, Lee M., Pelletier, Jonathan H., Hashmi, Hina N., Blais, Kayla, Velez, Alejandro, Gosse, Julie A.

Exposure to arsenic is a global health concern. We previously documented an inhibitory effect of inorganic Arsenite on IgE-mediated degranulation of RBL-2H3 mast cells (Hutchinson et al., 2011; J. Appl. Toxicol. 31: 231-241). Mast cells are tissue-re

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https://europepmc.org/articles/PMC5040607/

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Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events.

Autor: Shim J; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Kennedy RH; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine, 04469, USA., Weatherly LM; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine, 04469, USA., Hutchinson LM; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Pelletier JH; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Hashmi HN; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Blais K; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Velez A; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA., Gosse JA; Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, 04469, USA. Julie.gosse@maine.edu.; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine, 04469, USA. Julie.gosse@maine.edu.

Publikováno v: Journal of applied toxicology : JAT [J Appl Toxicol] 2016 Nov; Vol. 36 (11), pp. 1446-59. Date of Electronic Publication: 2016 Mar 28.