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High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion dynamics.

Autor: Sept CE; Department of Biostatistics, Harvard T.H. Chan School of Public Health; Boston, MA 02115, USA.; Department of Data Sciences, Dana-Farber Cancer Institute; Boston, MA 02115, USA.; Broad Institute of MIT and Harvard; Cambridge, MA 02142, USA., Tak YE; Molecular Pathology Unit, Massachusetts General Hospital; Charlestown, MA 02129, USA.; Department of Pathology, Harvard Medical School; Boston, MA 02115, USA., Cerda-Smith CG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA., Hutchinson HM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine; Durham, NC 27710, USA., Goel V; Broad Institute of MIT and Harvard; Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research; Cambridge, MA 02139, USA., Blanchette M; Dovetail Genomics, Cantata Bio LLC, Scotts Valley, CA 95066, USA., Bhakta MS; Dovetail Genomics, Cantata Bio LLC, Scotts Valley, CA 95066, USA., Hansen AS; Broad Institute of MIT and Harvard; Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research; Cambridge, MA 02139, USA., Joung JK; Molecular Pathology Unit, Massachusetts General Hospital; Charlestown, MA 02129, USA.; Department of Pathology, Harvard Medical School; Boston, MA 02115, USA., Johnstone S; Broad Institute of MIT and Harvard; Cambridge, MA 02142, USA.; Department of Pathology, Dana-Farber Cancer Institute; Boston, MA 02215, USA., Eyler CE; Department of Radiation Oncology, Duke University School of Medicine; Durham, NC 27710, USA.; Duke Cancer Institute, Duke University School of Medicine; Durham, NC 27710, USA., Aryee MJ; Department of Biostatistics, Harvard T.H. Chan School of Public Health; Boston, MA 02115, USA.; Department of Data Sciences, Dana-Farber Cancer Institute; Boston, MA 02115, USA.; Broad Institute of MIT and Harvard; Cambridge, MA 02142, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 28. Date of Electronic Publication: 2023 Oct 28.

MCB-613 exploits a collateral sensitivity in drug resistant EGFR -mutant non-small cell lung cancer through covalent inhibition of KEAP1.

Autor: Bassil CF; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Mayro B; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Askin KN; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Gruber S; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hall TM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hoj JP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Cerda-Smith C; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Hutchinson HM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Killarney ST; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Singleton KR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Qin L; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Jubien-Girard K; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR 7272 - 06108 Nice, France., Favreau C; Université Côte d'Azur, INSERM, C3M, Nice, France., Martin AR; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR 7272 - 06108 Nice, France.; IBMM, Université de Montpellier, ENSCM, CNRS, Montpellier, France., Robert G; Université Côte d'Azur, INSERM, C3M, Nice, France., Benhida R; Université Côte d'Azur, CNRS, Institut de Chimie de Nice UMR 7272 - 06108 Nice, France.; Chemical & Biochemical Sciences Green-Process Engineering (CBS) Mohammed VI Polytechnic University, Lot 660, Hay Moulay Rachid, Benguerir, Morocco., Auberger P; Université Côte d'Azur, INSERM, C3M, Nice, France., Pendergast AM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Lonard DM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Puissant A; Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 19. Date of Electronic Publication: 2023 Jan 19.