Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Hussein I. El Subbagh"'
Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules
Autor:
Ahmed A. Al-Karmalawy, Hussein I. El-Subbagh, Liliya Logoyda, Roman B. Lesyk, Mohammed I. El-Gamal
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/705aae411ab44b7ab48df9d52bc5f047
Autor:
Menna M. Abdelshaheed, Hussein I. El Subbagh, Mohamed A. Tantawy, Reem T. Attia, Khairia M. Youssef, Iten M. Fawzy
Publikováno v:
RSC Advances. 13:15689-15703
Compound 3b was designed and synthesized as pyrano-pyridine hybrid that showed high potency in the in vitro antiproliferative assay, 81% inhibition to polymerization of tubulin, high dynamic stability and 79% reduction in tumor size of breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d36c19818b6abb5efc0c3748ad2bd9b
https://doi.org/10.1039/d3ra02875e
https://doi.org/10.1039/d3ra02875e
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 4, Iss 1, Pp 1-7 (2018)
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described. Then, a series of hybrids have been developed by introducing Free radical scavengers.
Externí odkaz:
https://doaj.org/article/90e789ab5bf24b98854ce425b1baeb17
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 3, Iss 2, Pp 124-130 (2017)
Cucurbitacin E glucoside (1) is a tetracyclic triterpenoid glucoside, isolated from Cucurbitaceae plants. In the present study the pharmacological and biochemical effects of cucurbitacin-E-glucoside and two of its microbial transformation derivatives
Externí odkaz:
https://doaj.org/article/9958438cec7d4f8cbe30b5ffba024e32
Autor:
Nataliia Shulyak, Marjan Piponski, Sergiy Kovalenko, Tanja Bakovska Stoimenova, Trajan Balkanov, Hussein I. El-Subbagh, Iryna Drapak, Joy Oluwatobiloba Omotosho, Liliya Logoyda
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 2, p 16 (2021)
Our main target and concept was to develop a method for the determination of the most prescribed antilipemic drug, atorvastatin, together with its related substances, with a single sample preparation and during a single chromatographic run, in the sh
Externí odkaz:
https://doaj.org/article/5905058e7a034031959e1e189acdbfbf
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 1, Iss 2, Pp 50-56 (2015)
Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity t
Externí odkaz:
https://doaj.org/article/2258ab77a2be4ee0b5d6a38b2f47d9be
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 1, Iss 1, Pp 1-7 (2015)
The synthesis and the antitumor potential of 2-substituted aminothiazole-4-carboxylate, structurally-related to the antitumor antibiotic netropsin (NT) were reported. However, the exact mode of action and SAR of these compounds remained undefined. Cu
Externí odkaz:
https://doaj.org/article/57f9d29155a44ee08089e025c6b6718e
Autor:
Hussein I. El-Subbagh
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 21:1048-1057
Thiazolo- and thiadiazolo-[3,2-a][1,3]diazepines and their patented derivatives, tested with diverse CNS pharmacological activities, constitute an important class of compounds for new drug development. Therefore, research efforts were continued to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7688dc023cc1c50abc1d98be7a6840fb
https://doi.org/10.2174/1389557521999201230195733
https://doi.org/10.2174/1389557521999201230195733
Publikováno v:
European journal of medicinal chemistry. 241
New series of thiazole and imidazo[2,1-b]thiazole derivatives were synthesized and tested for their in vitro anticancer activity. Compounds 27, 34, 39 and 42-44 showed the best anticancer activity against the tested cancer cell lines with high safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b42a0903cb645d10b0c411d0f2b0436
https://pubmed.ncbi.nlm.nih.gov/35964425
https://pubmed.ncbi.nlm.nih.gov/35964425
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 87:129285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dbb1cc32e5564bf811443e9a4aa12fa
https://doi.org/10.1016/j.bmcl.2023.129285
https://doi.org/10.1016/j.bmcl.2023.129285