Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Hussein I. El‐Subbagh"'
Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules
Autor:
Ahmed A. Al-Karmalawy, Hussein I. El-Subbagh, Liliya Logoyda, Roman B. Lesyk, Mohammed I. El-Gamal
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/705aae411ab44b7ab48df9d52bc5f047
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 4, Iss 1, Pp 1-7 (2018)
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described. Then, a series of hybrids have been developed by introducing Free radical scavengers.
Externí odkaz:
https://doaj.org/article/90e789ab5bf24b98854ce425b1baeb17
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 3, Iss 2, Pp 124-130 (2017)
Cucurbitacin E glucoside (1) is a tetracyclic triterpenoid glucoside, isolated from Cucurbitaceae plants. In the present study the pharmacological and biochemical effects of cucurbitacin-E-glucoside and two of its microbial transformation derivatives
Externí odkaz:
https://doaj.org/article/9958438cec7d4f8cbe30b5ffba024e32
Autor:
Nataliia Shulyak, Marjan Piponski, Sergiy Kovalenko, Tanja Bakovska Stoimenova, Trajan Balkanov, Hussein I. El-Subbagh, Iryna Drapak, Joy Oluwatobiloba Omotosho, Liliya Logoyda
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 2, p 16 (2021)
Our main target and concept was to develop a method for the determination of the most prescribed antilipemic drug, atorvastatin, together with its related substances, with a single sample preparation and during a single chromatographic run, in the sh
Externí odkaz:
https://doaj.org/article/5905058e7a034031959e1e189acdbfbf
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 1, Iss 2, Pp 50-56 (2015)
Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity t
Externí odkaz:
https://doaj.org/article/2258ab77a2be4ee0b5d6a38b2f47d9be
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 1, Iss 1, Pp 1-7 (2015)
The synthesis and the antitumor potential of 2-substituted aminothiazole-4-carboxylate, structurally-related to the antitumor antibiotic netropsin (NT) were reported. However, the exact mode of action and SAR of these compounds remained undefined. Cu
Externí odkaz:
https://doaj.org/article/57f9d29155a44ee08089e025c6b6718e
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 6, Pp o1738-o1739 (2012)
The asymmetric unit of the title compound, C13H11BrN2OS, consists of two crystallographically independent molecules (A and B). In each molecule, the pyrrolidine ring adopts an envelope conformation with a methylene C atom as the flap atom. In molecul
Externí odkaz:
https://doaj.org/article/550f480cf2b44e6e88ecdc41e74a3c87
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 6, Pp o1665-o1665 (2012)
In the title compound, C18H22BrN3OS, the piperidine ring adopts a chair conformation. The mean plane of the thiazole ring forms dihedral angles of 23.97 (10) and 75.82 (10)° with the mean planes of its adjacent benzene and piperidine rings, respecti
Externí odkaz:
https://doaj.org/article/532e9cfb22e64e01b2a9774a28a32b7c
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hussein I. El-Subbagh, Suchada Chantrapromma, Hoong-Kun Fun
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 4, Pp o1074-o1075 (2012)
In the molecule of the title thioester, C14H12O2S, the dihedral angle between the phenyl and benzene rings is 71.8 (3)°. The methoxy group is essentially coplanar with the benezene ring to which it is bonded, with an r.m.s. deviation of 0.0065 (5)
Externí odkaz:
https://doaj.org/article/703650aa5afc4a8d96a33406d7502f64
Autor:
Menna M. Abdelshaheed, Hussein I. El Subbagh, Mohamed A. Tantawy, Reem T. Attia, Khairia M. Youssef, Iten M. Fawzy
Publikováno v:
RSC Advances. 13:15689-15703
Compound 3b was designed and synthesized as pyrano-pyridine hybrid that showed high potency in the in vitro antiproliferative assay, 81% inhibition to polymerization of tubulin, high dynamic stability and 79% reduction in tumor size of breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d36c19818b6abb5efc0c3748ad2bd9b
https://doi.org/10.1039/d3ra02875e
https://doi.org/10.1039/d3ra02875e