Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hussein Ghamlouch"'
Autor:
Hussein Ghamlouch, Eileen M. Boyle, Patrick Blaney, Yubao Wang, Jinyoung Choi, Louis Williams, Michael Bauer, Daniel Auclair, Benedetto Bruno, Brian A. Walker, Faith E. Davies, Gareth J. Morgan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-23 (2021)
Abstract Despite improvements in outcome, 15-25% of newly diagnosed multiple myeloma (MM) patients have treatment resistant high-risk (HR) disease with a poor survival. The lack of a genetic basis for HR has focused attention on the role played by ep
Externí odkaz:
https://doaj.org/article/461e41ddf12c4094a177bd08ae6ef5ec
Autor:
Riccardo Rigo, Rabie Chelbi, Julie Agopian, Sebastien Letard, Aurélien Griffon, Hussein Ghamlouch, Julien Vernerey, Vasileios Ladopoulos, Edwige Voisset, Paulo De Sepulveda, Geoffrey Guittard, Jacques A. Nunès, Ghislain Bidaut, Berthold Göttgens, Michael Weber, Olivier A. Bernard, Patrice Dubreuil, Erinn Soucie
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Mutation of the TET2 DNA-hydroxymethylase has been associated with a number of immune pathologies. The disparity in phenotype and clinical presentation among these pathologies leads to questions regarding the role of TET2 mutation in promoting diseas
Externí odkaz:
https://doaj.org/article/4730970c79894bdda7977a2e88bc7e6f
Autor:
Walaa Darwiche, Cathy Gomila, Hakim Ouled-Haddou, Marie Naudot, Cécile Doualle, Pierre Morel, Florence Nguyen-Khac, Loïc Garçon, Jean-Pierre Marolleau, Hussein Ghamlouch
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-17 (2020)
Abstract Background Novel, less toxic, cost-effective and safe therapeutic strategies are needed to improve treatment of chronic lymphocytic leukemia (CLL). Ascorbic acid (AA, vitamin C) has shown a potential anti-cancer therapeutic activity in sever
Externí odkaz:
https://doaj.org/article/13cae66a980843709d53f0d362d6be5a
Autor:
Fotini Kostopoulou, Clementine Gabillaud, Elise Chapiro, Beatrice Grange, Julie Tran, Simon Bouzy, Michael Degaud, Hussein Ghamlouch, Magali Le Garff‐Tavernier, Karim Maloum, Sylvain Choquet, Veronique Leblond, Jean Gabarre, Anne Lavaud, Veronique Morel, Damien Roos‐Weil, Madalina Uzunov, Romain Guieze, Olivier A. Bernard, Santos A. Susin, Olivier Tournilhac, Florence Nguyen‐Khac, the French Innovative Leukemia Organization (FILO) group
Publikováno v:
Cancer Medicine, Vol 8, Iss 6, Pp 3131-3141 (2019)
Abstract The different types of drug resistance encountered in chronic lymphocytic leukemia (CLL) cannot be fully accounted for by the 17p deletion (and/or TP53 mutation), a complex karyotype (CK), immunoglobulin heavy‐chain variable region genes (
Externí odkaz:
https://doaj.org/article/7d10de105bfe4bc180f4ac188592025d
Autor:
Dorothée Selimoglu-Buet, Julie Rivière, Hussein Ghamlouch, Laura Bencheikh, Catherine Lacout, Margot Morabito, M’boyba Diop, Guillaume Meurice, Marie Breckler, Aurélie Chauveau, Camille Debord, Franck Debeurme, Raphael Itzykson, Nicolas Chapuis, Christophe Willekens, Orianne Wagner-Ballon, Olivier A. Bernard, Nathalie Droin, Eric Solary
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
A decrease in the fraction of non-classical monocytes is a hallmark of chronic myelomonocytic leukaemia. Taking advantage of this abnormal situation, the authors identify a mechanistic link between miR-150 and TET3 as being involved in monocyte subse
Externí odkaz:
https://doaj.org/article/5d55187610e84c0189ca6173abd8c67a
Autor:
Enguerran Mouly, Hussein Ghamlouch, Veronique Della-Valle, Laurianne Scourzic, Cyril Quivoron, Damien Roos-Weil, Patrycja Pawlikowska, Véronique Saada, M'Boyba K. Diop, Cécile K. Lopez, Michaela Fontenay, Philippe Dessen, Ivo P. Touw, Thomas Mercher, Said Aoufouchi, Olivier A. Bernard
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 703-714 (2018)
Abstract: The TET2 gene encodes an α-ketoglutarate–dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in
Externí odkaz:
https://doaj.org/article/720969fbdbde47808b2dd1855942e27e
Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of small mature-looking CD19+ CD23+ CD5+ B-cells that accumulate in the blood, bone marrow, and lymphoid organs. To date, no consensus has been reached concerning the normal
Externí odkaz:
https://doaj.org/article/11af9c9e9dab439cbffe67755449ed6a
Autor:
Ingrid Marcq, Rémy Nyga, Flora Cartier, Rabbind Singh Amrathlal, Christèle Ossart, Hakim Ouled-Haddou, Hussein Ghamlouch, Antoine Galmiche, Denis Chatelain, Luciane Lamotte, Véronique Debuysscher, Vincent Fuentes, Eric Nguyen-Khac, Jean-Marc Regimbeau, Jean-Pierre Marolleau, Sylvain Latour, Hicham Bouhlal
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82918 (2013)
Although hepatocellular carcinoma (HCC) is one of the most common malignancies and constitutes the third leading cause of cancer-related deaths, the underlying molecular mechanisms are not fully understood. In the present study, we demonstrate for th
Externí odkaz:
https://doaj.org/article/3932ebdb48fb41f5a741bc4366cc3c90
Autor:
Hussein Ghamlouch, Hakim Ouled-Haddou, Gandhi Damaj, Bruno Royer, Brigitte Gubler, Jean-Pierre Marolleau
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60370 (2013)
B-chronic lymphocytic leukemia (B-CLL), the most common human leukemia, is characterized by predominantly non-dividing malignant mature CD5+ B lymphocytes with an apoptosis defect. Various microenvironmental stimuli confer a growth advantage on these
Externí odkaz:
https://doaj.org/article/dd77e1d06f0e4b24a2cebb3387257ae6
Autor:
Francesco Maura, Eileen Boyle, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Bachisio Ziccheddu, Hussein Ghamlouch, Yubao Wang, James E. Hoffman, Dickran Kazandjian, Hani Hassoun, Emily Guzman, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A. Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E. Davies, Saad Usmani, Neha Korde, Gareth J. Morgan, Ola Landgren
Publikováno v:
Blood. 140:1137-1139