Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hussein Abou-Issa"'
Autor:
Jamie M. Ahrens, Robert W. Curley, Margaret Clagett-Dame, Joel R. Walker, Hussein Abou-Issa, Nirca J. Nieves, Galal A. Alshafie
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:3038-3048
All-trans retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility has been hampered by dose-limiting side effects. The glucuronide derivatives of 4-HPR, the oxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5c85fd79cab96e733e0118a4d54d2a
https://doi.org/10.1016/j.bmc.2005.12.044
https://doi.org/10.1016/j.bmc.2005.12.044
Autor:
Hussein Abou-Issa, Galal A. Alshafie
Publikováno v:
Expert Review of Anticancer Therapy. 4:725-734
Lung cancer is by far the leading cause of cancer-related deaths. Overall survival is poor and has not improved substantially over the last 50 years. Therefore, it is clear that novel and more effective treatments are needed to improve the outcome of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26889915e4fb97bd5fb425a922bcb2d
https://doi.org/10.1586/14737140.4.5.725
https://doi.org/10.1586/14737140.4.5.725
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2447-2450
Retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventatives and chemotherapeutics for numerous types of cancer. The C-linked analogue of the O-glucuronide of 4-HPR (4-HPRCG) has been shown to be a more effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045fb5cbbfee5abd2973f0cc60cd1ef
https://doi.org/10.1016/s0960-894x(02)00427-4
https://doi.org/10.1016/s0960-894x(02)00427-4
Autor:
Kevin L. Weiss, Robert W. Curley, Serena M. Mershon, Galal A. Alshafie, Hussein Abou-Issa, Jason S. Chapman, Margaret Clagett-Dame
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1583-1586
The synthesis of a nonhydrolyzable, carbon-linked analogue (4-HBR) of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) using Umpolung methods is described. Preliminary studies of biological activity show 4-HBR is similar to 4-HPR in its actions alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e2d209ae25c84c64ce0ac9813925a9
https://doi.org/10.1016/s0960-894x(01)00230-x
https://doi.org/10.1016/s0960-894x(01)00230-x
Autor:
Galal A. Alshafie, Michelle L. Parrett, Hussein Abou-Issa, Mary S. Ross, Fredika M. Robertson, Randall E. Harris, Farahnaz S. Joarder
Publikováno v:
Cancer Letters. 122:165-175
A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a53358740387c6b657910bdd30e3106
https://doi.org/10.1016/s0304-3835(97)00387-x
https://doi.org/10.1016/s0304-3835(97)00387-x
Publikováno v:
Biochemical and Biophysical Research Communications. 208:688-696
The enzyme O6-alkylguanine DNA alkyltransferase (AGT) is implicated in the repair of DNA damage by chemotherapeutic chloroethylnitrosoureas (CNUs) and plays a vital role in determining the sensitivity of cancer cells to this class of compounds. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f0258b9e2e880ec4ae1a1bc0b89adf
https://doi.org/10.1006/bbrc.1995.1393
https://doi.org/10.1006/bbrc.1995.1393
Autor:
Margaret Clagett-Dame, Robert W. Curley, M. J. Robarge, S. Seth, Joyce J. Repa, Hussein Abou-Issa, Kristine K. Hanson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2117-2122
Glucuronide metabolites of retinoic acid (RA) and its analogs have been suggested to be active cancer chemopreventive/chemotherapeutic metabolites of the parent molecule. The glucuronide of RA is relatively unstable, thus we prepared N-linked glycosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3730291171a487be7019a04673a2bd6f
https://doi.org/10.1016/s0960-894x(01)80113-x
https://doi.org/10.1016/s0960-894x(01)80113-x
Autor:
Galal A. Alshafie, Jason S. Chapman, Margaret Clagett-Dame, Kevin L. Weiss, Robert W. Curley, Hussein Abou-Issa, Serena M. Mershon
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5679aa8a8d92edab2c8a6d1ee8187b9d
https://doi.org/10.1002/chin.200137224
https://doi.org/10.1002/chin.200137224
Publikováno v:
ChemInform. 33
Retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventatives and chemotherapeutics for numerous types of cancer. The C-linked analogue of the O-glucuronide of 4-HPR (4-HPRCG) has been shown to be a more effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85bc39c6a469f5914c8840a2531077c6
https://doi.org/10.1002/chin.200251202
https://doi.org/10.1002/chin.200251202
Autor:
Galal A, Alshafie, Joel R, Walker, Robert W, Curley, Margaret, Clagett-Dame, Margaret A, Highland, Nirca J, Nieves, Laura A, Stonerock, Hussein, Abou-Issa
Publikováno v:
Anticancer research. 25(3c)
Previous studies from our laboratory suggest that 4-HPROG, the O-glucuronide derivative of 4-HPR, has improved mammary cancer chemopreventive/ antitumor activities as well as reduced toxicity, as compared to 4-HPR. This O-linked glucuronide derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::560cef6ae58782f32bb48ada89babb91
https://pubmed.ncbi.nlm.nih.gov/16082771
https://pubmed.ncbi.nlm.nih.gov/16082771