Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment.

Autor: Zhu M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Frank MW; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Radka CD; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA., Jeanfavre S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xu J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Tse MW; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pacheco JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kim JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hussain FA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA., Elsherbini J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Hussain S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Xulu N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Khan N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Pillay V; Health Systems Trust, Durban, South Africa., Mitchell CM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA., Dong KL; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Health Systems Trust, Durban, South Africa; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Ndung'u T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany; Division of Infection and Immunity, University College London, London, UK., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rock CO; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Blainey PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: pblainey@broadinstitute.org., Bloom SM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA. Electronic address: smbloom@mgh.harvard.edu., Kwon DS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA. Electronic address: dkwon@mgh.harvard.edu.

Publikováno v: Cell [Cell] 2024 Sep 19; Vol. 187 (19), pp. 5413-5430.e29. Date of Electronic Publication: 2024 Aug 19.

Prevotella are major contributors of sialidases in the human vaginal microbiome.

Autor: Pelayo P; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138., Hussain FA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Cambridge, MA 02139., Werlang CA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139., Wu CM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139., Woolston BM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.; Department of Chemical Engineering, Northeastern University, Boston, MA 02115., Xiang CM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138., Rutt L; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201., France MT; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201., Ravel J; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201., Ribbeck K; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139., Kwon DS; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Cambridge, MA 02139., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.; HHMI, Harvard University, Cambridge, MA 02138.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Sep 03; Vol. 121 (36), pp. e2400341121. Date of Electronic Publication: 2024 Aug 26.

Tailless and filamentous prophages are predominant in marine Vibrio.

Autor: Steensen K; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria.; Doctoral School in Microbiology and Environmental Science, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria., Séneca J; Centre for Microbiology and Environmental Systems Science, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria.; Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria., Bartlau N; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria., Yu XA; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria., Hussain FA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 15 Vassar St., Cambridge MA 02138, United States., Polz MF; Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Vienna, Austria.

Publikováno v: The ISME journal [ISME J] 2024 Jan 08; Vol. 18 (1).

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment.

Autor: Zhu M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Frank MW; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Radka CD; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky., Jeanfavre S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tse MW; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pacheco JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xu J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Hussain S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Hussain FA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Xulu N; HIV Pathogenesis Programme (HPP), The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Khan N; HIV Pathogenesis Programme (HPP), The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., Pillay V; Health Systems Trust, Durban, South Africa., Dong KL; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Health Systems Trust, Durban, South Africa.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Ndung'u T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; HIV Pathogenesis Programme (HPP), The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute (AHRI), Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, UK., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rock CO; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; passed away on September 22, 2023., Blainey PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA, USA., Bloom SM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kwon DS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 30. Date of Electronic Publication: 2023 Dec 30.

Worldwide Prevalence of Epstein-Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis.

Autor: Al-Khreisat MJ; Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Ismail NH; Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Tabnjh A; Department of Applied Dental Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan., Hussain FA; Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Mohamed Yusoff AA; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Johan MF; Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Islam MA; WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Publikováno v: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jun 15; Vol. 13 (12). Date of Electronic Publication: 2023 Jun 15.