Adenosine Receptor Activation in the 'Trigger' Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s)

Autor: Hussain Contractor, MBChB, DPhil, Rasmus Haarup Lie, MD, PhD, Colin Cunnington, MBChB, DPhil, Jing Li, PhD, Nicolaj B. Støttrup, MD, PhD, Cedric Manlhiot, BSc, Hans Erik Bøtker, MD, PhD, Michael R. Schmidt, MD, PhD, J. Colin Forfar, MD, PhD, Houman Ashrafian, MB BChir, DPhil, Andrew Redington, MBBS, PhD, Rajesh K. Kharbanda, MBChB, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 1, Iss 6, Pp 461-471 (2016)

Remote ischemic pre-conditioning (rIPC) has emerged as a potential mechanism to reduce ischemia-reperfusion injury. Clinical data, however, have been mixed, and its physiological basis remains unclear, although it appears to involve release of circul

Externí odkaz: https://doaj.org/article/4f312fe7489742dbb66a77de0a7522bc

34 Next generation P2Y12 inhibitors improve survival in ACS: an analysis from the british cardiovascular intervention society database

Autor: Peter Woolfson, Nik Abidin, Simon G. Anderson, Lwin Tin, Sushant Saluja, Hussain Contractor, Fahmida Mannan, Scot Garg, Alan Fitchet

Publikováno v: Acute coronary syndromes & Interventional cardiology.

Background Dual antiplatelet therapy (DAPT) is the standard care following presentation with an acute coronary syndrome (ACS), but there remains debate regarding the relative benefits of the available P2Y12 receptor antagonists and their optimal comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::054517aa6b4db290c0e4808d99d385b5
https://doi.org/10.1136/heartjnl-2021-bcs.34

Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning

Autor: Kasper Pryds, Hussain Contractor, Jan Hansen, Michael Schmidt, Sivagowry Rasalingam Mørk, Hans Erik Bøtker, Jacob Johnsen, Rajesh K. Kharbanda, Petra Kleinbongard, Marie Hauerslev, Nichlas Riise Jespersen, Gerd Heusch

Publikováno v: Hauerslev, M, Mørk, S R, Pryds, K, Contractor, H, Hansen, J, Jespersen, N R, Johnsen, J, Heusch, G, Kleinbongard, P, Kharbanda, R, Bøtker, H E & Schmidt, M R 2018, ' Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning ', American Journal of Physiology-Heart and Circulatory Physiology, vol. 315, no. 1, pp. H150-H158 . https://doi.org/10.1152/ajpheart.00114.2018

Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Because of overlapping mechanisms, this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915f4687299ef692daa381baf1b411d7
https://pubmed.ncbi.nlm.nih.gov/29569958

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Autor: Timothy R. Graham, Nigel E Drury, David Green, Jorge Mascaro, Domenico Pagano, Stephen J. Rooney, Nick Freemantle, Neil J. Howell, Ian C. Wilson, Michael P. Frenneaux, Henrik Isackson, Robert S. Bonser, David W. Quinn, Hussain Contractor, Lynne Williams, Melanie Calvert, Aaron M. Ranasinghe, Houman Ashrafian

Background— Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34ec15dc6bb00f43e07c9f032333326
https://doi.org/10.1161/circulationaha.110.945170

Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury

Autor: Christian M, Pedersen, Sowmya, Venkatasubramanian, Henrik, Vase, Janus A, Hyldebrandt, Hussain, Contractor, Michael R, Schmidt, Hans Erik, Bøtker, Nicholas L, Cruden, David E, Newby, Rajesh K, Kharbanda, Ninian N, Lang

Publikováno v: British journal of clinical pharmacology. 81(6)

Ischaemia-reperfusion injury (IRI) causes impaired endothelial function and is a major component of the adverse effects of reperfusion following myocardial infarction. Rotigaptide increases gap junction conductance via connexin-43. We tested the hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc6a6df93d68f2b64c591c99e39356e2
https://pubmed.ncbi.nlm.nih.gov/26750458