Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Husheng Ding"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
Dong-Gi Mun, Firdous A. Bhat, Neha Joshi, Leticia Sandoval, Husheng Ding, Anu Jain, Jane A. Peterson, Taewook Kang, Ganesh P. Pujari, Jennifer L. Tomlinson, Rohit Budhraja, Roman M. Zenka, Nagarajan Kannan, Benjamin R. Kipp, Surendra Dasari, Alexandre Gaspar-Maia, Rory L. Smoot, Richard K. Kandasamy, Akhilesh Pandey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The rapid evolution of mass spectrometry-based single-cell proteomics now enables the cataloging of several thousand proteins from single cells. We investigated whether we could discover cellular heterogeneity beyond proteome, encompassing p
Externí odkaz:
https://doaj.org/article/41f4506afb6741688f7c4f83231b9391
Autor:
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze, Michael D Jensen, Nathan K LeBrasseur, Tamar Tchkonia, James L Kirkland
Publikováno v:
eLife, Vol 4 (2015)
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhi
Externí odkaz:
https://doaj.org/article/ec852c46c83c4207854436df1e2e57e8
Autor:
Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann
Publikováno v:
Haematologica, Vol 99, Iss 1 (2014)
Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers di
Externí odkaz:
https://doaj.org/article/c8ce24c260924fff83b4f73d3d068613
Autor:
Larry M. Karnitz, S. John Weroha, Aaron S. Mansfield, Scott H. Kaufmann, Ann L. Oberg, George Vasmatzis, Melissa C. Larson, Husheng Ding, Rebecca L. Kelly, Amelia M. Huehls, Valentina Zanfagnin, Thomas L. Ekstrom, Xiaonan Hou, Arun Kanakkanthara
PARP inhibitors (PARPi) have activity in homologous recombination (HR) repair-deficient, high-grade serous ovarian cancers (HGSOC). However, even responsive tumors develop PARPi resistance, highlighting the need to delay or prevent the appearance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e677b242d96f856734272a99d21e154
https://doi.org/10.1158/0008-5472.c.6570575.v1
https://doi.org/10.1158/0008-5472.c.6570575.v1
Autor:
Larry M. Karnitz, S. John Weroha, Aaron S. Mansfield, Scott H. Kaufmann, Ann L. Oberg, George Vasmatzis, Melissa C. Larson, Husheng Ding, Rebecca L. Kelly, Amelia M. Huehls, Valentina Zanfagnin, Thomas L. Ekstrom, Xiaonan Hou, Arun Kanakkanthara
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6416fe0aa2cfef5dc69fe7a060f4b72
https://doi.org/10.1158/0008-5472.22582412.v1
https://doi.org/10.1158/0008-5472.22582412.v1
Autor:
Larry M. Karnitz, S. John Weroha, Aaron S. Mansfield, Scott H. Kaufmann, Ann L. Oberg, George Vasmatzis, Melissa C. Larson, Husheng Ding, Rebecca L. Kelly, Amelia M. Huehls, Valentina Zanfagnin, Thomas L. Ekstrom, Xiaonan Hou, Arun Kanakkanthara
Supplementary Table S3. P-values for indicated PDX tumor growth comparisons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a246ce876c5ac0548c8d6a307c2e3eb
https://doi.org/10.1158/0008-5472.22582403
https://doi.org/10.1158/0008-5472.22582403
Autor:
Larry M. Karnitz, S. John Weroha, Aaron S. Mansfield, Scott H. Kaufmann, Ann L. Oberg, George Vasmatzis, Melissa C. Larson, Husheng Ding, Rebecca L. Kelly, Amelia M. Huehls, Valentina Zanfagnin, Thomas L. Ekstrom, Xiaonan Hou, Arun Kanakkanthara
Supplementary Figures 1-8 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f743d48f755a6f08ab52163932073
https://doi.org/10.1158/0008-5472.22582415.v1
https://doi.org/10.1158/0008-5472.22582415.v1
Autor:
Scott H. Kaufmann, Larry M. Karnitz, Hu Li, Keith W. Pratz, Judith E. Karp, B. Douglas Smith, Gabriel Ghiaur, Jonathan A. Webster, Mrinal Patnaik, Sun-Hee Lee, Cristina Correia, Kevin L. Peterson, Karen S. Flatten, Paula A. Schneider, X. Wei Meng, Annapoorna Venkatachalam, Brian D. Koh, Mira A. Kohorst, Cordelia D. McGehee, Nicole D. Vincelette, Husheng Ding
Supplementary methods, three supplementary tables and 16 supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc8d64060cf335d74052c55f5b1496f
https://doi.org/10.1158/0008-5472.22427530.v1
https://doi.org/10.1158/0008-5472.22427530.v1
Autor:
Scott H. Kaufmann, Larry M. Karnitz, Hu Li, Keith W. Pratz, Judith E. Karp, B. Douglas Smith, Gabriel Ghiaur, Jonathan A. Webster, Mrinal Patnaik, Sun-Hee Lee, Cristina Correia, Kevin L. Peterson, Karen S. Flatten, Paula A. Schneider, X. Wei Meng, Annapoorna Venkatachalam, Brian D. Koh, Mira A. Kohorst, Cordelia D. McGehee, Nicole D. Vincelette, Husheng Ding
Although inhibitors of the kinases CHK1, ATR, and WEE1 are undergoing clinical testing, it remains unclear how these three classes of agents kill susceptible cells and whether they utilize the same cytotoxic mechanism. Here we observed that CHK1 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e00427ec269deafe01c0b75797943fd
https://doi.org/10.1158/0008-5472.c.6512716.v1
https://doi.org/10.1158/0008-5472.c.6512716.v1