Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Hushan Zhang"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed to function as a negative regulator of p53 by facilitating its ubiquitination and subsequen
Externí odkaz:
https://doaj.org/article/6aea15e0e52d494e867b89ebde0b5798
Autor:
Zhengqi Wen, Wenliang Li, Chengmin Shi, Junrui Ma, Sihui Zhao, Ruize Zhou, Xihong Liu, Rong Yang, Zhiping Zhang, Hushan Zhang, Bo Li
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 100983- (2024)
Externí odkaz:
https://doaj.org/article/c6507a4980c84cb9b345e7f768ada967
Autor:
Chengmin Shi, Junrui Ma, Tong Zhang, Yanqiang Shi, Weiming Duan, Depei Huang, Hushan Zhang, Yujian Zeng
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-9 (2023)
Abstract Background Small bowel cancer (SBC) is a very rare solid malignancy. Consequently, compared with other malignant gastrointestinal tumors, our knowledge regarding SBC, specifically its molecular attributes, remains limited. Herein, we aim to
Externí odkaz:
https://doaj.org/article/1045fcd716634694a709f61ce59817f0
Autor:
Xiao-Ting Liu, Zhi-Yong Kou, Hushan Zhang, Jian Dong, Jian-Hua Zhang, You-Jun Peng, Shu Min Ma, Lei Liang, Xuan-Yu Meng, Yuan Zhou, Jun Yang
Publikováno v:
PeerJ, Vol 11, p e15261 (2023)
The status of human epidermal growth factor receptor 2 (HER2) for the prognosis in colorectal cancer (CRC) is controversial, and the characteristics of the somatic mutation spectrum, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-
Externí odkaz:
https://doaj.org/article/f8099acb048541078da28263dbf7714a
Autor:
Shu Wang, Guanghui Xu, Mengbin Li, Jiyang Zheng, Yuhao Wang, Xiangying Feng, Jialin Luo, Shibo Wang, Huan Liu, Weiming Duan, Hushan Zhang, Depei Huang, Feilong Zhao, Yongzhan Nie, Jianjun Yang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe efficacy and safety of immunotherapy have been widely recognized in gastrointestinal-related cancers. However, the efficacy of neoadjuvant camrelizumab for locally advanced esophageal squamous cell carcinoma (ESCC) has not been firmly
Externí odkaz:
https://doaj.org/article/4e531dd6930f481d9a736f0e367182d0
Autor:
Youming Lei, Kun Wang, Yinqiang Liu, Xuming Wang, Xudong Xiang, Xiangu Ning, Wanbao Ding, Jin Duan, Dingbiao Li, Wei Zhao, Yi Li, Fujun Zhang, Xiaoyu Luo, Yunfei Shi, Ying Wang, Depei Huang, Yuezong Bai, Hushan Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion of EGFR subtypes in NSCLC and evaluated the TMB level, PD-L1 expression level and tumor immune microenvironment among different EGFR mutation subtypes.
Externí odkaz:
https://doaj.org/article/24ceb5d835864657bd071c07447030d1
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Osimertinib shows strong clinical activity in first- and second-line treatment of nonsmall-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, especially EGFR T790M. However, when patients develop resistance, the
Externí odkaz:
https://doaj.org/article/ff0e5250c91a42b3b319ac7f8139c7ee
Autor:
Xiaolong Zhao, Fuqiang Dai, Longyong Mei, Depei Huang, Xudong Shen, Hushan Zhang, Xueke She, Zheng Ma
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundPostoperative circulation tumor DNA (ctDNA) is a promising method to predict the risk of recurrence. However, the amount of ctDNA in patients with early NSCLC is too small. Cell damages caused during the intraoperative period leads to a sig
Externí odkaz:
https://doaj.org/article/80252b09eb3a404bacd8f9277e47d18e
Autor:
Jun Yang, Zhengqi Wen, Wenliang Li, Xianghua Sun, Junrui Ma, Xueke She, Hongbin Zhang, Changling Tu, Guoqiang Wang, Depei Huang, Xudong Shen, Jian Dong, Hushan Zhang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fib
Externí odkaz:
https://doaj.org/article/6c8acd3ca05d4ea8b1ecd0c805475734
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Gastric cancer is one of the most common cancers, while the current treatment options for gastric cancer are relatively scarce due to insufficient understanding of molecular characteristics and subtypes of gastric cancer. Different gene rearrangement
Externí odkaz:
https://doaj.org/article/59ddfa77cc344b5282b4e8b2c6e46375