Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Huseyin Saribasak"'
Autor:
Hiroshi Arakawa, George-Lucian Moldovan, Huseyin Saribasak, Nesibe Nur Saribasak, Stefan Jentsch, Jean-Marie Buerstedde
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e366 (2006)
Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replica
Externí odkaz:
https://doaj.org/article/06721dd8b6824b728333a91a571b999a
Publikováno v:
PLoS Biology, Vol 2, Iss 7, p E179 (2004)
Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation.
Externí odkaz:
https://doaj.org/article/3b7e841a4700475cb4a4761554aa5200
The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Autor:
David G. Schatz, Jagan M. R. Pongubala, Craig H. Bassing, Anurupa Devi Yadavalli, Huseyin Saribasak, Anamika Bhattacharyya, Rebecca A Glynn, Elizabeth Corbett, Rahul Arya, Helen A. Beilinson, Jianxiong Xiao, Charline Miot, Jessica M. Jones
Publikováno v:
The Journal of experimental medicine. 218(10)
Immunoglobulin and T cell receptor gene assembly depends on V(D)J recombination initiated by the RAG1-RAG2 recombinase. The RAG1 N-terminal region (NTR; aa 1–383) has been implicated in regulatory functions whose influence on V(D)J recombination an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fb5de5e169cdbab0f1254043bb52c6
https://pubmed.ncbi.nlm.nih.gov/34402853
https://pubmed.ncbi.nlm.nih.gov/34402853
Publikováno v:
Blood Cancer Discovery. 1:PO-23
Somatic hypermutation (SHM) is a B cell-specific process that supports the affinity maturation of antibodies. The reaction targets the immunoglobulin loci (“on-target" activity) and is initiated by activation-induced cytidine deaminase (AID). AID i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9eb09f22a19394098a83f7a62aed220
https://doi.org/10.1158/2643-3249.lymphoma20-po-23
https://doi.org/10.1158/2643-3249.lymphoma20-po-23
Autor:
Robert W. Maul, Jennifer T. Fox, Diana P. Castiblanco, Yong Jun Choi, William W. Yang, Patricia J. Gearhart, Kimberly J. Zanotti, Huseyin Saribasak, Kyungjae Myung
Publikováno v:
The Journal of Immunology. 194:35-42
Mammalian ATPase family AAA domain–containing protein 5 (ATAD5) and its yeast homolog enhanced level of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly synthesized DNA. Prior work in HeLa and yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3878fc88c53fd254c39913a79a245b
https://doi.org/10.4049/jimmunol.1401158
https://doi.org/10.4049/jimmunol.1401158
Autor:
Sven Kracker, Zheng Cao, Dominik Schenten, Huseyin Saribasak, William W. Yang, Patricia J. Gearhart, Robert W. Maul
Publikováno v:
The Journal of Experimental Medicine
Genetic inactivation of the genes encoding several low-fidelity DNA polymerases indicates that DNA polymerase ζ inserts tandem double-base substitutions in the immunoglobulin variable region in mouse B cells.
Low-fidelity DNA polymerases introd
Low-fidelity DNA polymerases introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef56f7688e78922d915d71b636fba4d
http://europepmc.org/articles/PMC3371727
http://europepmc.org/articles/PMC3371727
Autor:
Zheng Cao, Huseyin Saribasak, David M. Wilson, William W. Yang, Patricia J. Gearhart, Rhonda L. McClure, Robert W. Maul, Daniel R. McNeill
Publikováno v:
The Journal of Experimental Medicine
As revealed using mice heterozygous for the base excision repair (BER) protein XRCC1, BER and mutagenic repair pathways can simultaneously compete for access to single-strand breaks induced by activation-induced deaminase.
Activation-induced dea
Activation-induced dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2198e57c424422cd4003c798b1ffcd
https://doi.org/10.1084/jem.20111135
https://doi.org/10.1084/jem.20111135
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 364:605-611
Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6873bf0dfb1bf4ea419b497df5fa4a
https://doi.org/10.1098/rstb.2008.0188
https://doi.org/10.1098/rstb.2008.0188
Publikováno v:
DNA Repair. 7:1603-1608
DNA polymerase θ has been implicated in the process of somatic hypermutation in immunoglobulin variable genes based on several reports of alterations in the frequency and spectra of mutations from Polq −/− mice. However, these studies have contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ade77dd003c093f83df2802ba97c914
https://doi.org/10.1016/j.dnarep.2008.04.002
https://doi.org/10.1016/j.dnarep.2008.04.002
Autor:
Sabine S. Lange, Ekaterina G. Frank, William W. Yang, Roger Woodgate, Mary P. McLenigan, Patricia J. Gearhart, Thomas MacCarthy, Katherine A. Donigan, Huseyin Saribasak, Robert W. Maul, Donald Huston
Publikováno v:
The Journal of Experimental Medicine
Gearhart and collaborators address the long-standing question of the roles of error-prone DNA polymerases in somatic hypermutation of antibody genes.
DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody gen
DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df94dfe7b8854d2ac6693379d417dde
https://pubmed.ncbi.nlm.nih.gov/27455952
https://pubmed.ncbi.nlm.nih.gov/27455952