Výsledky vyhledávání - "Husayn A. Pallikonda"

Akademický článek

The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocy

Externí odkaz: https://doaj.org/article/ce6d54e4a05749d99545339b720e286a

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Data from Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

Autor: Samra Turajlic, Mariam Jamal-Hanjani, Charles Swanton, Kevin Litchfield, James Larkin, Anna Green, Ula Mahadeva, Ruby Stewart, Lisa Pickering, Andrew J.S. Furness, Kate Young, Emma L. Nye, Gordon W.H. Stamp, Ian Proctor, Mary Falzon, David A. Moore, Miriam Mitchison, Elaine Borg, Cristina Naceur-Lombardelli, Jun Murai, Maise Al Bakir, Nicholas McGranahan, Ariana Huebner, Hang Xu, Aljosja Rogiers, Robert Mason, Joanna Lynch, Husayn Ahmed Pallikonda, Camille L. Gerard, Max Emmerich, Anne-Laure Cattin, Molly O'Flaherty, Charlotte Lewis, Justine Korteweg, Aida Murra, Jennifer Biano, Denise Kelly, Lauren Terry, Mary Mangwende, Sarah Vaughan, Sarah Sarker, Kayleigh Kelly, Kema Peat, Lauren Grostate, Karla Lingard, Zayd Tippu, Andreas M. Schmitt, Charlotte Spencer, Diana C.J. Spierings, Rene Wardenaar, Hilda van den Bos, Floris Foijer, Jaime Nobbs, Peta Hughes, Christina Messiou, Alexandra Renn, Nikki Hunter, Eleanor Carlyle, Kim Edmonds, Lewis Au, Elisa Piperni, Maria Goicoechea, Fiona Byrne, Benjamin Shum, Scott T.C. Shepherd, Desiree Schnidrig, Andrew Rowan, Irene Lobon, Alexander Coulton, Lavinia Spain

Understanding the evolutionary pathways to metastasis and resistance to immune-checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present the most comprehensive intrapatient metastatic melanoma dataset assembled to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682740b5baa2c65d53e95cea4595dfad
https://doi.org/10.1158/2159-8290.c.6649132

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Supplementary Figures S1-S25 from Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

Supplementary figure 1: Cohort overview. Number of samples sequenced with whole exome, panel or whole RNA sequencing. Supplementary figure 2: Phylogeny and WGD events in CRUKP1047. Supplementary figure 3: Ploidy and SCNA burden. Supplementary figure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f79ce57c107fe296590c39e19d1d2e6
https://doi.org/10.1158/2159-8290.22841335.v1

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Supplementary Tables S1-S8 from Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

S. Table 1: List of PEACE Consortium members. S. Table 2: Sample database used for the study for Panel, Exome and RNASeq samples. S. Table 3: Overview of lines of treatment given to each patient. S. Table 4: Lesions and patients included in the lesio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ff6cf95efc3203d7876d1cbdc0ba2e
https://doi.org/10.1158/2159-8290.22841332

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Predicting cancer evolution for patient benefit: Renal cell carcinoma paradigm

Autor: Husayn Ahmed Pallikonda, Samra Turajlic

Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1877:188759

Evolutionary features of cancer have important clinical implications, but their evaluation in the clinic is currently limited. Here, we review current approaches to reconstruct tumour subclonal structure setting and discuss tumour sampling method and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59b9bb4b60a9d53be456e4836fb88c2
https://doi.org/10.1016/j.bbcan.2022.188759

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The order and logic of CD4 CD8 lineage choice and differentiation in mouse thymus

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

CD4 and CD8 mark helper and cytotoxic T cell lineages, respectively, and serve as coreceptors for MHC-restricted TCR recognition. How coreceptor expression is matched with TCR specificity is central to understanding CD4/CD8 lineage choice, but visual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3168d4b6f6b0266d637e78435346469
http://hdl.handle.net/10044/1/85325

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