Výsledky vyhledávání - "Husam Nawafleh"

Akademický článek

Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells

Autor: Raefa Abou Khouzam, Mohak Sharda, Shyama Prasad Rao, Stephanie Maame Kyerewah-Kersi, Nagwa Ahmed Zeinelabdin, Ayda Shah Mahmood, Husam Nawafleh, Munazza Samar Khan, Goutham Hassan Venkatesh, Salem Chouaib

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Hypoxia afflicts the microenvironment of solid tumors fueling malignancy. We investigated the impact of long hypoxia exposure on transcriptional remodeling, tumor mutational burden (TMB), and genomic instability of cancer cells that were grouped base

Externí odkaz: https://doaj.org/article/6fed90ce929d4c819d8d8363db37fa79

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Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity

Autor: Rania Faouzi Zaarour, Mohak Sharda, Bilal Azakir, Goutham Hassan Venkatesh, Raefa Abou Khouzam, Ayesha Rifath, Zohra Nausheen Nizami, Fatima Abdullah, Fatin Mohammad, Hajar Karaali, Husam Nawafleh, Yehya Elsayed, Salem Chouaib

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6848

The role of autophagy in lung cancer cells exposed to waterpipe smoke (WPS) is not known. Because of the important role of autophagy in tumor resistance and progression, we investigated its relationship with WP smoking. We first showed that WPS activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457c56d67a2ef613aa8be280eb30f35e

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Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell lines

Autor: Francis Amirtharaj, Husam Nawafleh, Ayesha Rifath, Raefa Abou Khouzam, Rania Faouzi Zaarour, Nagwa Ahmed Zeinelabdin, Prathibha Prasad, Salem Chouaib, Goutham Hassan Venkatesh, Yehya El Sayed, Stephane Terry

Publikováno v: Oncology Reports

Waterpipe tobacco smoking (WPS) continues to spread globally and presents serious health hazards. The aim of the present study was to investigate the effects of treatment with WPS condensate (WPSC) on lung cell proliferation and plasticity as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a71d547880260b01861fd294752b50d
http://europepmc.org/articles/PMC7859923

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Abstract 2995: Autophagy as a key driver of waterpipe smoke-induced lung cancer cell plasticity and resistance

Autor: Rania F. Zaarour, Mohak Sharda, Bilal Azakir, Goutham Hassan Venkatesh, Raefa Abou Khouzam, Ayesha Rifath, Zohra Nizami, Fatima Abdullah, Fatin Mohammad, Husam Nawafleh, Yehia ElSayed, Salem Chouaib

Publikováno v: Cancer Research. 82:2995-2995

Smoking is the number one risk factor for lung cancer and tobacco smokers are at 20 to 40 times higher risk of developing lung cancer in comparison to non-smokers. We have previously shown that exposing lung cancer cell lines to tobacco smoke condens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74636fc74e624f82b35bc43e6e675985
https://doi.org/10.1158/1538-7445.am2022-2995

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Abstract 5679: Application of a hypoxia metric to investigate tumor mutational burden and cancer cell immunogenicity in vitro

Autor: Raefa Abou Khouzam, Nagwa Ahmed Zeinelabdin, Mohak Sharda, Husam Nawafleh, Ayda shah Mahmood, Munazza Samar Khan, Goutham Hassan Venkatesh, Salem Chouaib, Shyama Prasad Rao

Publikováno v: Cancer Research. 82:5679-5679

Hypoxia afflicts the microenvironment of solid tumors fueling tumor malignancy. Using an 8-gene in vitro hypoxia signature, we have recently shown that pancreatic cancer patients with highly hypoxic tumors experience worse survival and exhibit marker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0311296bf5b331a6ac9989bce21c0a2
https://doi.org/10.1158/1538-7445.am2022-5679

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Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

Autor: Rania Faouzi Zaarour, Colin Jamora, Agnete S.T. Engelsen, Edries Y. Hajam, Nagwa Ahmed Zeinelabdin, Salem Chouaib, Husam Nawafleh, Bilal A. Azakir, Jérome Thiery

Publikováno v: Cancers, Vol 13, Iss 533, p 533 (2021)
Cancers

Simple Summary Autophagy is a self-eating mechanism that is involved in the degradation of organelles and cellular materials. It is initiated by intracellular and extracellular stress stimuli. In the context of tumor development, microenvironmental h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd8bc37b5281e62288e87f7f14cc6d
https://www.mdpi.com/2072-6694/13/3/533

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Hypoxia increases mutational load of breast cancer cells through frameshift mutations

Autor: Francis Amirtharaj, Kapaettu Satyamoorthy, Walid El-Sayed, Philippe Dessen, Raefa Abou Khouzam, Jerome Thiery, Filippo Rosselli, Goutham Hassan Venkatesh, Salem Chouaib, Husam Nawafleh, Sandeep Mallya, Pamela Bravo, Bartosz Wojtas

Publikováno v: OncoImmunology
OncoImmunology, Taylor & Francis, 2020, 9 (1), pp.1750750. ⟨10.1080/2162402X.2020.1750750⟩
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology

International audience; Tumor hypoxia-induced downregulation of DNA repair pathways and enhanced replication stress are potential sources of genomic instability. A plethora of genetic changes such as point mutations, large deletions and duplications,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903d900c1da208b38376e7e95bc22880
https://hal.archives-ouvertes.fr/hal-03085616

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