Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Husam M Abu-Soud"'
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous functional endocrine disorder associated with a low-grade, chronic inflammatory state. Patients with PCOS present an increased risk of metabolic comorbidities and often menstrual dysregulat
Externí odkaz:
https://doaj.org/article/5c0d0ea048fe44b5a9990412dc455bc5
Autor:
Faten Shaeib, Sana N Khan, Mili Thakur, Hamid-Reza Kohan-Ghadr, Sascha Drewlo, Ghassan M Saed, Subramaniam Pennathur, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151160 (2016)
Myeloperoxidase (MPO), an abundant heme-containing enzyme present in neutrophils, monocytes, and macrophages, is produced in high levels during inflammation, and associated with poor reproductive outcomes. MPO is known to generate hypochlorous acid (
Externí odkaz:
https://doaj.org/article/e65ed48692764f0eb060f45fe889aee6
Autor:
Sana N Khan, Faten Shaeib, Tohid Najafi, Mahendra Kavdia, Bernard Gonik, Ghassan M Saed, Pravin T Goud, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132388 (2015)
Hydrogen peroxide (H2O2) is a relatively long-lived signaling molecule that plays an essential role in oocyte maturation, implantation, as well as early embryonic development. Exposure to relatively high levels of H2O2 functions efficiently to accele
Externí odkaz:
https://doaj.org/article/3e01c96eac504e9fb9403bf640036ca2
Autor:
Faten Shaeib, Sana N Khan, Iyad Ali, Tohid Najafi, Dhiman Maitra, Ibrahim Abdulhamid, Ghassan M Saed, Subramaniam Pennathur, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120737 (2015)
Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron. Here we show that the presence of melatonin (MLT) can pr
Externí odkaz:
https://doaj.org/article/96a78c36047442b8973884c033838ac5
Autor:
Pravin T Goud, Anuradha P Goud, Tohid Najafi, Bernard Gonik, Michael P Diamond, Ghassan M Saed, Xueji Zhang, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98720 (2014)
Nitric oxide (NO) is reported to play significant a role in oocyte activation and maturation, implantation, and early embryonic development. Previously we have shown that NO forms an important component of the oocyte microenvironment, and functions e
Externí odkaz:
https://doaj.org/article/cc5a43cad42348aabb378a017be6ce77
Autor:
Dhiman Maitra, Iyad Ali, Rasha M Abdulridha, Faten Shaeib, Sana N Khan, Ghassan M Saed, Subramaniam Pennathur, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110595 (2014)
Hypochlorous acid (HOCl) is a potent oxidant generated by myeloperoxidase (MPO), which is an abundant enzyme used for defense against microbes. We examined the potential role of HOCl in corrin ring destruction and subsequent formation of cyanogen chl
Externí odkaz:
https://doaj.org/article/1a39001e398c4f2cac7582f1663e0f1a
Autor:
Jashoman Banerjee, Rakesh Sharma, Ashok Agarwal, Dhiman Maitra, Michael P Diamond, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35535 (2012)
Interleukin 6 (IL-6) is considered a major indicator of the acute-phase inflammatory response. Endometriosis and pelvic inflammation, diseases that manifest elevated levels of IL-6, are commonly associated with higher infertility. However, the mechan
Externí odkaz:
https://doaj.org/article/1e36aa5a4751414fa984c8103d2e4350
Autor:
Carlos Eduardo A Souza, Dhiman Maitra, Ghassan M Saed, Michael P Diamond, Arlindo A Moura, Subramaniam Pennathur, Husam M Abu-Soud
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27641 (2011)
Lactoperoxidase (LPO) is the major consumer of hydrogen peroxide (H(2)O(2)) in the airways through its ability to oxidize thiocyanate (SCN(-)) to produce hypothiocyanous acid, an antimicrobial agent. In nasal inflammatory diseases, such as cystic fib
Externí odkaz:
https://doaj.org/article/8c0562b6fec24e2b8c915d890645f093
Autor:
Olivia G. Camp, Anuradha P. Goud, Pravin T. Goud, David Bai, Awoniyi Awonuga, Husam M. Abu-Soud
Publikováno v:
F&S Science. 4:114-120
Publikováno v:
Nitric Oxide. 124:32-38
Inducible nitric oxide synthase (iNOS) is a zinc-containing hemoprotein composed of two identical subunits, each containing a reductase and an oxygenase domain. The reductase domain contains binding sites for NADPH, FAD, FMN, and tightly bound calmod