Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Husam Alwan"'
Publikováno v:
Iraqi Geological Journal, Vol 56, Iss 2E, Pp 146-159 (2023)
Precipitation generating surface runoff is very important in various water resources development and management activities such as flood control and management, irrigation scheduling, irrigation design, and drainage networks. The aim of this study is
Externí odkaz:
https://doaj.org/article/b4dac21742514bfc80ccce75240cbabc
Autor:
Jon Read, Kevin Michael Foote, Johannes Wilhelmus Maria Nissink, Alan Lau, Louise Goodwin, Lisa Wissler, Jason Breed, Benjamin Taylor, Nichola L. Davies, Husam Alwan, James S. Scott, Jason Grant Kettle, Kay Eckersley, D.R Jones, Michal Bista, Marta Wylot, Graeme Walker, Shaun M. Fillery, Helena Käck
Publikováno v:
Journal of Medicinal Chemistry. 59:2346-2361
Recent literature has claimed that inhibition of the enzyme MTH1 can eradicate cancer. MTH1 is one of the "housekeeping" enzymes that are responsible for hydrolyzing damaged nucleotides in cells and thus prevent them from being incorporated into DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da178d427c92c2b105e4b0b1f3a2bf
https://doi.org/10.1021/acs.jmedchem.5b01760
https://doi.org/10.1021/acs.jmedchem.5b01760
Autor:
Joost C.M. Uitdehaag, Husam Alwan, Jos de Man, Guido J.R. Zaman, Folkert Verkaar, R.C. Buijsman
Publikováno v:
British Journal of Pharmacology. 166:858-876
To establish the druggability of a target, genetic validation needs to be supplemented with pharmacological validation. Pharmacological studies, especially in the kinase field, are hampered by the fact that many reference inhibitors are not fully sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c33cf77597343c2ee944a403c88b243
https://doi.org/10.1111/j.1476-5381.2012.01859.x
https://doi.org/10.1111/j.1476-5381.2012.01859.x
Autor:
Husam Alwan, Thierry Dorval, Kevin Hudson, Nikki Carter, Ronald T. Hay, J. Willem M. Nissink, Timurs Maculins
Publikováno v:
Scientific Reports
Ubiquitin signalling regulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases. E3 ubiquitin ligases provide substrate selectivity in ubiquitylation cascades and are therefore considered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaba548b4f4691e2fc000c34a02a8e3
https://pubmed.ncbi.nlm.nih.gov/26743172
https://pubmed.ncbi.nlm.nih.gov/26743172
Autor:
Kevin Michael Foote, David Jones, James S. Scott, Graeme Walker, Jason Grant Kettle, Benjamin J. M. Taylor, Husam Alwan, Jon Read, Louise Goodwin, Alan Lau, Kay Eckersley, Willem M. Nissink
Publikováno v:
Molecular Cancer Therapeutics. 14:C59-C59
Human mutT homolog MTH1 (also known as NUDT1) is a purine nucleoside triphosphatase which hydrolyses oxidised nucleotides (8-oxo-dGTP and 2-OH-dATP) into mono-phosphate forms to prevent these damaged bases from being incorporated into DNA. Recent stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59273dad85dcc2febfa20a93b5ab361f
https://doi.org/10.1158/1535-7163.targ-15-c59
https://doi.org/10.1158/1535-7163.targ-15-c59