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of 83
pro vyhledávání: '"Husain, Kabir"'
Autor:
Ravasio, Riccardo, Husain, Kabir, Evans, Constantine G., Phillips, Rob, Ribezzi, Marco, Szostak, Jack W., Murugan, Arvind
Extant life contains numerous non-equilibrium mechanisms to create order not achievable at equilibrium; it is generally assumed that these mechanisms evolved because the resulting order was sufficiently beneficial to overcome associated costs of time
Externí odkaz:
http://arxiv.org/abs/2405.10911
The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that active, physica
Externí odkaz:
http://arxiv.org/abs/2204.04838
Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requires several dedicated structural features in the enzyme, such as a nucl
Externí odkaz:
http://arxiv.org/abs/2005.11615
Autor:
Husain, Kabir, Murugan, Arvind
Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are unclear. Here, we demonstrate that the physical dynamics of a biological s
Externí odkaz:
http://arxiv.org/abs/1910.09491
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such `generalists' can be hard to evolve, out-competed by specialists fitter in any particular environment. Here, inspired by the search for
Externí odkaz:
http://arxiv.org/abs/1906.11924
Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \textit{Synechococcus elongatus} can naturally tune its environmental sensitivity,
Externí odkaz:
http://arxiv.org/abs/1903.07103
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Jun 01. 117(23), 12693-12699.
Externí odkaz:
https://www.jstor.org/stable/26968311
Autor:
Husain, Kabir, Krishna, Sandeep
The mean completion time of a stochastic process may be rendered finite and minimised by a judiciously chosen restart protocol, which may either be stochastic or deterministic. Here we study analytically an arbitrary stochastic search subject to an a
Externí odkaz:
http://arxiv.org/abs/1609.03754
Autor:
Husain, Kabir, Rao, Madan
Publikováno v:
Phys. Rev. Lett. 118, 078104 (2017)
Spatially localised defect structures emerge spontaneously in a hydrodynamic description of an active polar fluid comprising polar 'actin' filaments and 'myosin' motor proteins that (un)bind to filaments and exert active contractile stresses. These e
Externí odkaz:
http://arxiv.org/abs/1605.00149
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