Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics.

Autor: Rajczewski AT; Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota55455, United States., Ndreu L; Department of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden., Vryonidis E; Department of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden., Hurben AK; Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota55455, United States., Jamshidi S; Department of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden., Griffin TJ; Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota55455, United States., Törnqvist MÅ; Department of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden., Tretyakova NY; Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota55455, United States., Karlsson I; Department of Environmental Science, Stockholm University, SE-10691Stockholm, Sweden.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2023 Dec 18; Vol. 36 (12), pp. 2019-2030. Date of Electronic Publication: 2023 Nov 14.

Developing Role for Artificial Intelligence in Drug Discovery in Drug Design, Development, and Safety Assessment.

Autor: Hurben AK; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Erber L; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2022 Nov 21; Vol. 35 (11), pp. 1925-1928. Date of Electronic Publication: 2022 Sep 30.

Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II).

Autor: Weirath NA; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-147 CCRB, Minneapolis, Minnesota 55455, United States., Hurben AK; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-147 CCRB, Minneapolis, Minnesota 55455, United States., Chao C; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-147 CCRB, Minneapolis, Minnesota 55455, United States., Pujari SS; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-147 CCRB, Minneapolis, Minnesota 55455, United States., Cheng T; The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, United States., Liu S; The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, United States., Tretyakova NY; Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-147 CCRB, Minneapolis, Minnesota 55455, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Apr 21; Vol. 13 (5), pp. 792-798. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).

DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA.

Autor: Pujari SS; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA., Jokipii Krueger CC; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA., Chao C; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA., Hutchins S; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA., Hurben AK; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA., Boysen G; Department of Environmental and Occupational Health and the Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham St., Slot 820, Little Rock, AR, 72205, USA., Tretyakova N; Department of Medicinal Chemistry, College of Pharmacy, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Jan 13; Vol. 28 (3), pp. e202103245. Date of Electronic Publication: 2021 Dec 02.

Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca .

Autor: Alexander EM; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Kreitler DF; Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203, United States., Guidolin V; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, United States., Hurben AK; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Drake E; Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203, United States., Villalta PW; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Balbo S; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, United States., Gulick AM; Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203, United States., Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2020 Jul 10; Vol. 6 (7), pp. 1976-1997. Date of Electronic Publication: 2020 Jun 24.