ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.

Autor: Niknejad N; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Fox D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas, USA., Burwinkel JL; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Zarrin-Khameh N; Department of Pathology and Immunology, Baylor College of Medicine and Ben Taub Hospital, Houston, Texas, USA., Cho S; Development, Disease Models and Therapeutics Graduate Program, Baylor College of Medicine, Houston, Texas, USA., Soriano A; Ionis Pharmaceuticals, Carlsbad, California, USA., Cast AE; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Lopez MF; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Huppert KA; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Rigo F; Ionis Pharmaceuticals, Carlsbad, California, USA., Huppert SS; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Jafar-Nejad P; Ionis Pharmaceuticals, Carlsbad, California, USA., Jafar-Nejad H; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Genetics and Genomics Graduate Program, Baylor College of Medicine, Houston, Texas, USA.; Development, Disease Models and Therapeutics Graduate Program, Baylor College of Medicine, Houston, Texas, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2023 Nov 01; Vol. 78 (5), pp. 1337-1351. Date of Electronic Publication: 2023 Apr 07.

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation.

Autor: Schaub JR; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Huppert KA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kurial SNT; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Hsu BY; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Cast AE; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Donnelly B; Department of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Karns RA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Chen F; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Rezvani M; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Luu HY; Department of Surgery, Division of General Surgery, University of California San Francisco, San Francisco, CA, USA., Mattis AN; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Liver Center, University of California San Francisco, San Francisco, CA, USA., Rougemont AL; Department of Genetic and Laboratory Medicine, Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland., Rosenthal P; Liver Center, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of California San Francisco, San Francisco, CA, USA., Huppert SS; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. stacey.huppert@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. stacey.huppert@cchmc.org., Willenbring H; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA. holger.willenbring@ucsf.edu.; Liver Center, University of California San Francisco, San Francisco, CA, USA. holger.willenbring@ucsf.edu.; Department of Surgery, Division of Transplant Surgery, University of California San Francisco, San Francisco, CA, USA. holger.willenbring@ucsf.edu.

Publikováno v: Nature [Nature] 2018 May; Vol. 557 (7704), pp. 247-251. Date of Electronic Publication: 2018 May 02.

Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo.

Autor: Walter TJ; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee; and Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Cast AE; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Huppert KA; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Huppert SS; Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio Stacey.Huppert@cchmc.org.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2014 May 15; Vol. 306 (10), pp. G849-62. Date of Electronic Publication: 2014 Mar 20.

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.

Autor: Thorne CA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-8240, USA., Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2011 Oct; Vol. 16 (9), pp. 995-1006. Date of Electronic Publication: 2011 Aug 21.

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.

Autor: Sparks EE; Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Huppert KA, Brown MA, Washington MK, Huppert SS

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2010 Apr; Vol. 51 (4), pp. 1391-400.