Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Huocong Huang"'
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
Autor:
Yichi Zhang, Matthieu Dos Santos, Huocong Huang, Kenian Chen, Puneeth Iyengar, Rodney Infante, Patricio M. Polanco, Rolf A. Brekken, Chunyu Cai, Ambar Caijgas, Karla Cano Hernandez, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114587- (2024)
Summary: Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscle
Externí odkaz:
https://doaj.org/article/178060e694dc445f9c9795570d7dc38d
Autor:
Havish S. Kantheti, Michael A. Hale, Shreoshi Pal Choudhuri, Huocong Huang, Xu-dong Wang, Yalda Zolghadri, Giulio Innamorati, Sai Prasada Rao Manikonda, Naviya Reddy, Sarthak Reddy, Rahul K. Kollipara, Valbona Lumani, Luc Girard, Yakov Bezrukov, Pavel Demenkov, Raymond J. MacDonald, Rolf A. Brekken, Yonghao Yu, Thomas M. Wilkie
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6619 (2024)
Diagnostic markers are desperately needed for the early detection of pancreatic ductal adenocarcinoma (PDA). We describe sets of markers expressed in temporal order in mouse models during pancreatitis, PDA initiation and progression. Cell type specif
Externí odkaz:
https://doaj.org/article/ca0ca2e8a45e4004ad47086feb150789
Autor:
Ajay Dixit, Aaron Sarver, Jon Zettervall, Huocong Huang, Kexin Zheng, Rolf A. Brekken, Paolo P. Provenzano
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Pancreatic ductal adenocarcinoma (PDA) remains resistant to immune therapies, largely owing to robustly fibrotic and immunosuppressive tumor microenvironments. It has been postulated that excessive accumulation of immunosuppressive myeloid cells infl
Externí odkaz:
https://doaj.org/article/dc7eef9351654893b8a124a012fbb9ef
Autor:
Yuqing Zhang, Huocong Huang, Morgan Coleman, Arturas Ziemys, Purva Gopal, Syed M. Kazmi, Rolf A. Brekken
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor–A (hereafter VEGF). As a result, anti-VEGF therapy is commonly used for cancer treatment. Recent studies have found that VEGF expression is also associated with im
Externí odkaz:
https://doaj.org/article/678c51832205427eb6542fc20f36712b
Autor:
Jenying Deng, Yaan Kang, Chien-Chia Cheng, Xinqun Li, Bingbing Dai, Matthew H. Katz, Taoyan Men, Michael P. Kim, Eugene A. Koay, Huocong Huang, Rolf A. Brekken, Jason B. Fleming
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote cancer progression. A central mediator of protumorigenic collagen signaling is the receptor
Externí odkaz:
https://doaj.org/article/6534f5a2324842ac8f6e0b149ce8159e
Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
Autor:
Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 11, Pp n/a-n/a (2019)
Abstract TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we
Externí odkaz:
https://doaj.org/article/7541d711b35f4c639b31ee32955e251b
Autor:
Kangsan Kim, Huocong Huang, Pravat Kumar Parida, Lan He, Mauricio Marquez-Palencia, Tanner C. Reese, Payal Kapur, James Brugarolas, Rolf A. Brekken, Srinivas Malladi
Publikováno v:
Cancer Discovery. 13:85-97
Cell competition, a fitness-sensing process, is essential for tissue homeostasis. Using cancer metastatic latency models, we show that cell competition results in the displacement of latent metastatic (Lat-M) cells from the primary tumor. Lat-M cells
Autor:
Srinivas Malladi, Rolf A. Brekken, James Brugarolas, Payal Kapur, Tanner C. Reese, Mauricio Marquez-Palencia, Lan He, Pravat Kumar Parida, Huocong Huang, Kangsan Kim
Video shows displacement of Lat-M cells in cell competition. Lat-M cells (Green) surrounded by PA (Red) cells being displaced under cell competition assay conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dd367810891989ccf128e24eb5a514
https://doi.org/10.1158/2159-8290.22541746
https://doi.org/10.1158/2159-8290.22541746
Autor:
Srinivas Malladi, Rolf A. Brekken, James Brugarolas, Payal Kapur, Tanner C. Reese, Mauricio Marquez-Palencia, Lan He, Pravat Kumar Parida, Huocong Huang, Kangsan Kim
Cell competition, a fitness-sensing process, is essential for tissue homeostasis. Using cancer metastatic latency models, we show that cell competition results in the displacement of latent metastatic (Lat-M) cells from the primary tumor. Lat-M cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65093bf8d2813d82a60f8ce40fa696a3
https://doi.org/10.1158/2159-8290.c.6549736.v1
https://doi.org/10.1158/2159-8290.c.6549736.v1
Autor:
Srinivas Malladi, Rolf A. Brekken, James Brugarolas, Payal Kapur, Tanner C. Reese, Mauricio Marquez-Palencia, Lan He, Pravat Kumar Parida, Huocong Huang, Kangsan Kim
This document includes the followings: Supplementary Fig. S1-6 and legends Supplementary Table. S1-2 and legends Supplementary Video. S1 legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1822792cf125c0b8717546ec808fd242
https://doi.org/10.1158/2159-8290.22541749
https://doi.org/10.1158/2159-8290.22541749