Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses

Autor: Siu-Ying Lau, Qingbing Zheng, Jun Wu, Yanning Liu, Hai Yu, Honglin Chen, Zhenhua Zheng, Lin Xia, Ningshao Xia, Yixin Chen, Wenxin Luo, Huo Yongting, Wai Lan Wu

Publikováno v: Antimicrobial agents and chemotherapy. 55(4)

Highly pathogenic H5N1 virus infection causes severe disease and a high rate of fatality in humans. Development of humanized monoclonal antibodies may provide an efficient therapeutic regime for H5N1 virus infection. In the present study, broadly cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e21782275e5ef7a7221458133dc206
https://pubmed.ncbi.nlm.nih.gov/21245446

A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation.

Autor: Yang Y; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Zhang J; Medical Research Center Yuebei People's Hospital, Shantou University Medical College Shaoguan China.; Shenzhen Immunity Biotech Co., Ltd. Shenzhen China., Zhang S; State Key Laboratory of Respiratory Disease National Clinical Researcher Center for Respiratory Diseases Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China., Zhang C; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Shen C; BSL-3 Laboratory (Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Department of Laboratory Medicine Zhujiang Hospital Southern Medical University Guangzhou China., Song S; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Wang Y; State Key Laboratory of Respiratory Disease National Clinical Researcher Center for Respiratory Diseases Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China., Peng Y; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Gong X; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Dai J; Health and Quarantine Laboratory Guangzhou Customs District Technology Centre Guangzhou Guangdong China., Xie C; Medical Research Center Yuebei People's Hospital, Shantou University Medical College Shaoguan China.; Shenzhen Immunity Biotech Co., Ltd. Shenzhen China., Khrustaleva TA; Multidisciplinary Diagnostic Laboratory Institute of Physiology of the National Academy of Sciences of Belarus Minsk Belarus., Khrustalev VV; Multidisciplinary Diagnostic Laboratory Institute of Physiology of the National Academy of Sciences of Belarus Minsk Belarus., Huo Y; Guangdong Fapon Biopharma Inc. Shenzhen China., Lu D; Guangdong Fapon Biopharma Inc. Shenzhen China., Yao D; Department of Thoracic Surgery The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Shenzhen Guangdong China., Zhao J; State Key Laboratory of Respiratory Disease National Clinical Researcher Center for Respiratory Diseases Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China., Liu Y; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China., Lu H; Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Clinical Research Center for infectious disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China.

Publikováno v: Exploration (Beijing, China) [Exploration (Beijing)] 2023 Dec 15; Vol. 4 (3), pp. 20230086. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2024).