Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Autor: Aebi J; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Atz K; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Ametamey SM; Center for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland., Benz J; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Blaising J; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Butini S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy., Carreira EM; Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland., Collin L; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., De Lago E; Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Gazzi T; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Gertsch J; Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland., Gobbi L; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Guba W; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Fernández-Ruiz J; Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Fingerle J; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Haider A; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., He Y; Center for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland., Heitman LH; Division of Drug Discovery and Safety, Leiden University, Netherlands., Honer M; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Hunziker D; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Kuhn B; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Maccarrone M; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.; European Center for Brain Research, Santa Lucia Foundation, 00128 Rome, Italy., Märki HP; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Martin RE; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Mohr P; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Mu L; Center for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland., Nazaré M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, Germany., Nippa DF; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Oddi S; Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.; European Center for Brain Research (CERC)/Santa Lucia Foundation, 00179 Rome, Italy., O'Hara F; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Pacher P; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, United States of America., Romero J; Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, Spain., Röver S; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Rufer AC; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland. uwe.grether@roche.com., Schibli R; Center for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland., Schneider G; ETH Zurich, Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland., Stepan AF; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Sykes DA; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, England.; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, England., Ullmer C; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Veprintsev DB; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, England.; European Center for Brain Research, Santa Lucia Foundation, 00128 Rome, Italy., Wittwer MB; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland., Grether U; Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel. uwe.grether@roche.com.

Publikováno v: Chimia [Chimia (Aarau)] 2024 Aug 21; Vol. 78 (7-8), pp. 499-512. Date of Electronic Publication: 2024 Aug 21.

Creosote Bush. Biology and Chemistry of Larrea in New World Deserts T. J. Mabry J. H. Hunziker D. R. Difeo, Jr.

Publikováno v: Journal of Range Management, 1978 Sep 01. 31(5), 399-399.

Externí odkaz: https://www.jstor.org/stable/3897371

Mesquite & Creosote Mesquite: Its Biology in Two Desert Scrub Ecosystems B. Simpson Creosote Bush: Biology and Chemistry of Larrea in New World Deserts T. J. Mabey J. H. Hunziker D. R. DiFeo, Jr

Autor: William G. McGinnies, Steven P. McLaughlin

Publikováno v: BioScience. 29:486-486

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b2dfc06b149037c7cd5d001a1bd0f85
https://doi.org/10.2307/1307550

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Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor.

Autor: Hunziker D; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Reinehr S; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Palmhof M; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Wagner N; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Biniasch T; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Stute G; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Mattei P; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Schmitz P; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., DiGiorgio P; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Hert J; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Rudolph MG; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Benz J; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Stihle M; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Gsell B; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Müller S; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland., Gasser R; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Therapeutic Modalities, Small Molecule Research, Roche Innovation Center Basel, Basel, Switzerland.; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Schonhoven N; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany., Ullmer C; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, Basel, Switzerland., Joachim SC; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2022 Jan 18; Vol. 12, pp. 699535. Date of Electronic Publication: 2022 Jan 18 (Print Publication: 2021).