Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential.

Autor: Pierre HC; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu., Amrine CSM; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.; Department of Physical and Earth Sciences. Arkansas Tech University, 1701 N. Boulder Ave., Russellville, Arkansas 72801, USA., Doyle MG; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu., Salvi A; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Ave (M/C 870), Chicago, Illinois 60607, USA., Raja HA; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu., Chekan JR; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, Ohio 43210, USA., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, Ohio 43210, USA., Liu K; Department of Biochemistry and Molecular Biology and the Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, USA., Burdette JE; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Ave (M/C 870), Chicago, Illinois 60607, USA., Pearce CJ; Mycosynthetix, Inc., Hillsborough, NC, 27278, USA., Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, North Carolina 27402, USA. nicholas_oberlies@uncg.edu.

Publikováno v: Natural product reports [Nat Prod Rep] 2024 Sep 18; Vol. 41 (9), pp. 1327-1345. Date of Electronic Publication: 2024 Sep 18.

PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.

Autor: Salvi A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Young AN; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Pergande MR; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Korkmaz MA; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Rathnayake RA; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Mize BK; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Zhang X; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, 43210, USA., Ratia K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Schirle M; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Thomas JR; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Brittain SM; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Shelton C; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Aldrich LN; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Cologna SM; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Burdette JE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA. joannab@uic.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Jan 10; Vol. 13 (1), pp. 45. Date of Electronic Publication: 2022 Jan 10.

Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Autor: Young AN; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois., Herrera D; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio., Korkmaz MA; Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois., Lantvit DD; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois., Mazumder S; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., Kolli S; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., Coss CC; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., King S; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., Wang H; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., Swanson SM; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, Wisconsin., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio., Zhang X; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio., Phelps MA; Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio., Aldrich LN; Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio., Burdette JE; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois. joannab@uic.edu.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Oct; Vol. 17 (10), pp. 2123-2135. Date of Electronic Publication: 2018 Jul 17.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Autor: Oghumu S; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Varikuti S; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Saljoughian N; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Terrazas C; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Huntsman AC; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Parinandi NL; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Fuchs JR; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Kinghorn AD; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States., Satoskar AR; College of Public Health, §College of Pharmacy, and ∥Department of Microbiology, The Ohio State University , Columbus, Ohio 43210, United States.; Department of Pathology and ⊥Department of Internal Medicine, The Ohio State University Medical Center , Columbus, Ohio 43210, United States.

Publikováno v: Journal of natural products [J Nat Prod] 2017 Sep 22; Vol. 80 (9), pp. 2515-2523. Date of Electronic Publication: 2017 Sep 06.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Autor: Gupta G; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States.; Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of Sao Paulo , Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, Brazil., Peine KJ; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Abdelhamid D; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Department of Medicinal Chemistry, Minia University , Minia, Egypt., Snider H; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Shelton AB; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Rao L; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Kotha SR; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Varikuti S; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Oghumu S; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Naman CB; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Pan L; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Parinandi NL; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Papenfuss TL; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University , 1900 Coffey Road, Columbus, Ohio 43210, United States.; Department of Pathology, WIL Research , Ashland, Ohio 55805, United States., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Bachelder EM; Division of Pharmaceutics, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Ainslie KM; Division of Pharmaceutics, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Satoskar AR; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2015 Oct 09; Vol. 1 (10), pp. 497-506. Date of Electronic Publication: 2015 Sep 21.