Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Huntly, Brian JP"'
Autor:
Woodley, Keith, Dillingh, Laura S, Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M, Philippe, Céline, Dembitz, Vilma, Magee, Aoife MS, Asby, Ryan, Van De Lagemaat, Louie N, Mapperley, Christopher, James, Sophie C, Prehn, Jochen HM, Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S, Kranc, Kamil R, Helgason, G Vignir, Huntly, Brian JP, Gallipoli, Paolo
Funder: American Society of Hematology (ASH); doi: https://doi.org/10.13039/100001422
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations whic
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759490005d7fd4928880f19e42b86468
https://www.repository.cam.ac.uk/handle/1810/348664
https://www.repository.cam.ac.uk/handle/1810/348664
Recurrent gene mutations often cooperate in a predefined stepwise and synergistic manner to alter global transcription, through directly or indirectly remodeling epigenetic landscape on linear and three-dimensional (3D) scales. Here, we present a mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5998057f63123390d17027e7bf99fd77
Autor:
Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J, Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M, Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S, Vassiliou, George S, Huntly, Brian JP
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ff66507743d639bf3fd87b6689bb9d
https://www.repository.cam.ac.uk/handle/1810/326699
https://www.repository.cam.ac.uk/handle/1810/326699
Autor:
Marando, Ludovica, Huntly, Brian JP
Bromodomain and extra terminal (BET) proteins comprise the ubiquitously expressed BRD2, BRD3, BRD4 and the testes specific BRDT. These multipurpose proteins contain tandem N-terminal bromodomains that bind acetylated lysine residues of histone (and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8c8ffaa646642183877f6600fe6774
Autor:
Gallipoli, Paolo, Huntly, Brian Jp
The presence of internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis to acute myeloid leukemia (AML) patients. Now, specific structural features of the ITD are also suggested to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::0b51970214b4be9655c865d12f7dfdd5
https://www.repository.cam.ac.uk/handle/1810/286784
https://www.repository.cam.ac.uk/handle/1810/286784
Autor:
Giotopoulos, George, Huntly, Brian JP
In this issue of Cancer Cell, de Boer et al. refine a set of acute myeloid leukemia (AML)-enriched plasma membrane markers that can be used to identify, prospectively isolate, and longitudinally track leukemic subclones within individual AML patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c96e447ec9f1fd4f3dc5f0f0243b1c
https://www.repository.cam.ac.uk/handle/1810/285862
https://www.repository.cam.ac.uk/handle/1810/285862
Autor:
Sasca, Daniel, Huntly, Brian JP
A new study provides the first insights into epigenetic heterogeneity in AML. The study highlights a striking independence of genetic and epigenetic variation, and links the kinetics of epigenetic change to clinical outcome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956193c4c29742831e563afa210eddb5
Autor:
Bench, Anthony J, Nacheva, Elisabeth P, Hood, Tracey L, Holden, Jane L, French, Lisa, Swanton, Soheila, Champion, Kim M, Li, Juan, Whittaker, Pamela, Stavrides, George, Hunt, Adrienne R, Huntly, Brian JP, Campbell, Lynda J, Bentley, David R, Deloukas, Panos
Publikováno v:
Oncogene; 8/10/2000, Vol. 19 Issue 34, p3902, 12p
Autor:
Kvinlaug, Brynn T, Huntly, Brian JP
Publikováno v:
Expert Opinion on Therapeutic Targets; July 2007, Vol. 11 Issue: 7 p915-927, 13p
Autor:
Koo, Sumin *, Mercher, Thomas *, Freeman, Shannon Mckinney *, Wang, Yuan *, Ball, Brian *, Huntly, Brian JP *, Bansal, Dimple *, Daley, George Q., Gilliland, D. Gary
Publikováno v:
In Blood 16 November 2008 112(11):1404-1404