Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease

Autor: Ido Rippin, Katherina Bonder, Shirley Joseph, Ammar Sarsor, Lilach Vaks, Hagit Eldar-Finkelman

Publikováno v: Neurobiology of Disease, Vol 154, Iss , Pp 105336- (2021)

In Huntington's disease (HD), the mutant huntingtin (mHtt) accumulates as toxic aggregates in the striatum tissue, with deleterious effects on motor-coordination and cognitive functions. Reducing the levels of mHtt is therefore a promising therapeuti

Externí odkaz: https://doaj.org/article/046c34e9ec654364a9ccf8bd0fb54142

Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease

Autor: Shirley Ben Joseph, Lilach Vaks, Amar Sarsor, Ido Rippin, Katherina Bonder, Hagit Eldar-Finkelman

Publikováno v: Neurobiology of Disease, Vol 154, Iss, Pp 105336-(2021)

In Huntington's disease (HD), the mutant huntingtin (mHtt) accumulates as toxic aggregates in the striatum tissue, with deleterious effects on motor-coordination and cognitive functions. Reducing the levels of mHtt is therefore a promising therapeuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82430bd6e6a6fc9dbff5516f0ea00373
https://pubmed.ncbi.nlm.nih.gov/33753290

Role of metabolism in neurodegenerative disorders

Autor: Giuseppe Matarese, Mario Galgani, Luigi Formisano, Paola de Candia, Alessandra Colamatteo, Claudio Procaccini, Marianna Santopaolo, Deriggio Faicchia, Veronica De Rosa

Publikováno v: Metabolism, clinical and experimental (Online) 65 (2016): 1376–1390. doi:10.1016/j.metabol.2016.05.018
info:cnr-pdr/source/autori:Procaccini C.; Santopaolo M.; Faicchia D.; Colamatteo A.; Formisano L.; De Candia P.; Galgani M.; De Rosa V.; Matarese G./titolo:Role of metabolism in neurodegenerative disorders/doi:10.1016%2Fj.metabol.2016.05.018/rivista:Metabolism, clinical and experimental (Online)/anno:2016/pagina_da:1376/pagina_a:1390/intervallo_pagine:1376–1390/volume:65

Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc7c017da9884fd6154bd830667bb04
https://doi.org/10.1016/j.metabol.2016.05.018

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Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases

Autor: Hussain, B., hina Khalid, Nadeem, S., Sultana, T., Aslam, S.

Publikováno v: International Journal Bioautomation, Vol 16, Iss 3, Pp 165-178 (2012)
Scopus-Elsevier

It is evident that Neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's) have many similarities at cellular and molecular level as they carry parallel mechanisms including protein aggregation and inclusion body formation caused by pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7078615dc6033dd35f0c1ee973b917f9
http://www.clbme.bas.bg/bioautomation/2012/vol_16.3/files/16.3_02.pdf