Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hunter Shain"'
Autor:
Dan Daniel Erdmann-Pham, Sanjit Singh Batra, Timothy K. Turkalo, James Durbin, Marco Blanchette, Iwei Yeh, Hunter Shain, Boris C. Bastian, Yun S. Song, Daniel S. Rokhsar, Dirk Hockemeyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chromosomal rearrangements can initiate and drive cancer progression, yet it has been challenging to evaluate their impact, especially in genetically heterogeneous solid cancers. To address this problem we developed HiDENSEC, a new computati
Externí odkaz:
https://doaj.org/article/ed3755dd242a46369848794dde819c04
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Acral and mucosal melanomas are aggressive subtypes of melanoma, which have a significantly lower burden of somatic mutations than cutaneous melanomas, but more frequent copy number variations, focused gene amplifications, and str
Externí odkaz:
https://doaj.org/article/5506dfad06f743f88764cdd2fecdfc01
Autor:
Darwin Chang, A. Hunter Shain
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Cutaneous squamous cell carcinoma is a form of skin cancer originating from keratinocytes in the skin. It is the second most common type of cancer and is responsible for an estimated 8000 deaths per year in the United States. Compared to oth
Externí odkaz:
https://doaj.org/article/bab85fd9a5dc44c494d95b0c9848c502
Autor:
Wei Cao, Hayan Lee, Wei Wu, Aubhishek Zaman, Sean McCorkle, Ming Yan, Justin Chen, Qinghe Xing, Nasa Sinnott-Armstrong, Hongen Xu, M. Reza Sailani, Wenxue Tang, Yuanbo Cui, Jia liu, Hongyan Guan, Pengju Lv, Xiaoyan Sun, Lei Sun, Pengli Han, Yanan Lou, Jing Chang, Jinwu Wang, Yuchi Gao, Jiancheng Guo, Gundolf Schenk, Alan Hunter Shain, Fred G. Biddle, Eric Collisson, Michael Snyder, Trever G. Bivona
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methy
Externí odkaz:
https://doaj.org/article/2d7895e7d5f748e48174da98ff21c531
Autor:
Andrew S McNeal, Rachel L Belote, Hanlin Zeng, Marcus Urquijo, Kendra Barker, Rodrigo Torres, Meghan Curtin, A Hunter Shain, Robert HI Andtbacka, Sheri Holmen, David H Lum, Timothy H McCalmont, Matt W VanBrocklin, Douglas Grossman, Maria L Wei, Ursula E Lang, Robert L Judson-Torres
Publikováno v:
eLife, Vol 10 (2021)
Benign melanocytic nevi frequently emerge when an acquired BRAFV600E mutation triggers unchecked proliferation and subsequent arrest in melanocytes. Recent observations have challenged the role of oncogene-induced senescence in melanocytic nevus form
Externí odkaz:
https://doaj.org/article/53ad9d885af34b1391f8b61352342926
Autor:
Iwei Yeh, Ursula E. Lang, Emeline Durieux, Meng Kian Tee, Aparna Jorapur, A. Hunter Shain, Veronique Haddad, Daniel Pissaloux, Xu Chen, Lorenzo Cerroni, Robert L. Judson, Philip E. LeBoit, Timothy H. McCalmont, Boris C. Bastian, Arnaud de la Fouchardière
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the clas
Externí odkaz:
https://doaj.org/article/fbd6a7307720476793d06dd7588353f5
Autor:
Thomas Botton, Eric Talevich, Vivek Kumar Mishra, Tongwu Zhang, A. Hunter Shain, Céline Berquet, Alexander Gagnon, Robert L. Judson, Robert Ballotti, Antoni Ribas, Meenhard Herlyn, Stéphane Rocchi, Kevin M. Brown, Nicholas K. Hayward, Iwei Yeh, Boris C. Bastian
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 573-588.e7 (2019)
Summary: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected hete
Externí odkaz:
https://doaj.org/article/0cc277c61e1b4388ac070ad9ad16b2a2
