Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Hunter C Champion"'
Autor:
Trinity J Bivalacqua, Biljana Musicki, Lewis L Hsu, Dan E Berkowitz, Hunter C Champion, Arthur L Burnett
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68028 (2013)
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Externí odkaz:
https://doaj.org/article/ac3dbbbaeaae4bbea80a540255ca723c
Autor:
Daniel J Kass, Eileen Rattigan, Rehan Kahloon, Katrina Loh, Liyang Yu, Asaf Savir, Mark Markowski, Anjali Saqi, Revathi Rajkumar, Ferhaan Ahmad, Hunter C Champion
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35388 (2012)
Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in hu
Externí odkaz:
https://doaj.org/article/59fd5451027a48728db6a208fe8916e3
Autor:
Horst Olschewski, Andrew Nelsen, Eric Shen, Meredith Broderick, Stacy Mandras, Hunter C. Champion, Gabor Kovacs
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics
Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder characterized by vascular remodeling of the small pulmonary arteries, resulting in elevated pulmonary vascular resistance and ultimately, right ventricular failure. Expanded
Autor:
R. James White, Samuel Glickman, Robert Ambrosini, Shanti Akers, Daniel J. Lachant, Serban A. Staicu, David F. Meoli, Hunter C. Champion, Deborah Haight
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 317(4)
Pulmonary arterial hypertension (PAH) is a female predominant disease in which progressive vascular remodeling and vasoconstriction result in right ventricular (RV) failure and death. Most PAH patients utilize multiple therapies. In contrast, the maj
Autor:
Trinity J. Bivalacqua, Hunter C. Champion, Philip J. Kadowitz, Dennis B. McNamara, Albert L. Hyman
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 2 (2001)
Responses to angiotensin II (Ang II) were investigated in anaesthetised CD1 mice. Injections of Ang II caused dose-related increases in systemic arterial pressure that were antagonised by candesartan. Responses to Ang II were not altered by PD 123319
Publikováno v:
Circulation Research. 115:115-130
Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction and vascular remodeling obstruct small pulmonary arteries, resulting in increased pulmonary vascular resistance and pulmonary pressures. This leads to reduced
Autor:
M. Patricia George, Hunter C. Champion, Renee Weinman, Mark T. Gladwin, Deborah McMahon, Christopher D. Lacomis, Alison Morris, Marc A. Simon, Cathy Kessinger
Publikováno v:
Journal of cardiac failure, vol 20, iss 6
BackgroundHIV-infected individuals are at increased risk for pulmonary hypertension and cardiomyopathy, portending a poor prognosis. Right ventricular (RV) dysfunction is associated with worse outcomes in these conditions, yet its prevalence is poorl
Autor:
Mohammad Shatat, Jason S. Fritz, José Martínez-González, Hongmei Tian, Anne Hamik, Gaurav Tandon, Mukesh K. Jain, Guangjin Zhou, Hunter C. Champion, Cristina Rodríguez, Rongli Zhang, Andrew T. Hale
Publikováno v:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Krüppel-like factor 4 (KLF4) is a transcription factor expressed in the vascular endothelium, where it promotes anti-inflammatory and anticoagulant states, and increases endothelial nitric oxide synthase expression. We examined the role of endotheli
Autor:
Patrick J. Pagano, Sruti Shiva, Jeffrey J. Baust, Imad Al Ghouleh, Giovanna Frazziano, Hunter C. Champion
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 306:H197-H205
Pulmonary arterial hypertension is a severe progressive disease with marked morbidity and high mortality in which right ventricular (RV) failure is the major cause of death. Thus knowledge of the mechanisms underlying RV failure is an area of active
Autor:
Enrico M. Novelli, Mark A. Ross, Claudette M. St. Croix, Heather E. Knupp, Maria G. Frid, Luciano Mazzaro, Maryam Sharifi-Sanjani, Mingyi Yao, John Sembrat, Revathi Rajkumar, Hunter C. Champion, Mark T. Gladwin, Jadranka Milosevic, Ferhaan Ahmad, Kurt R. Stenmark, Jeffrey S. Isenberg, Kendall S. Hunter, Natasha M. Rogers, M. Patricia George
Publikováno v:
Pulmonary Circulation. 3:936-951
Pulmonary hypertension is recognized as a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). We now report benchtop phenotyping from the explanted lungs of the first successful lung transplant in SCD. Pulmonary arter