Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hunter, S. Iain"'
Autor:
Lesnik, Urska, Fujs, Stefan, Raspor, Peter, Hranueli, Daslav, Hunter, S. Iain, Petković, Hrvoje
Many phenotypic characteristics that are associated with differentiation and secondary metabolism are genetically unstable, including aerial mycelium formation, pigmentation, sporulation, resistance to antibiotics, and/or antibiotic production. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::03b54e786f1c83fd41335fb6518de032
https://www.bib.irb.hr/253922
https://www.bib.irb.hr/253922
Autor:
Paravić Radičević, Andrea, Denapaite, Dalia, Čajavec, Branka, Hunter, S. Iain, Hranueli, Daslav, Cullum, John
Historically, the Streptomycetes were classified as fungi, with which they share a common habitat and superficial appearance. Subsequently, they were classified correctly as bacteria - based on their histology, biochemical composition and genetics. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::28673d28d0385774747a8a99924cf124
https://www.bib.irb.hr/120367
https://www.bib.irb.hr/120367
OtcC encodes a hydroxylase that acts at the 6-position of the tetracyclic nucleus, after it has beenformed. OtcC is located at the edge of the otc cluster, distant (and transcribed separately) from the genes for biosynthesis of the polyketide backbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::b54372490fb6e3ccace51c0e3541db08
https://www.bib.irb.hr/87053
https://www.bib.irb.hr/87053
Recent advances in the molecular genetics of Streptomyces have increased our understanding of polyketide antibiotic biosynthesis, to the point where recombinant DNA approaches to generate novel structures are possible. Our understanding of how antibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::01dbb59de12641e7d43f38a51ea4e603
https://www.bib.irb.hr/39077
https://www.bib.irb.hr/39077
The gene cluster for biosynthesis of the polyketide antibiotic oxytetracycline (OTC) has been cloned from Streptomyces rimosus. A systematic strategy to characterize each gene is to identify the metabolite(s) made by a recombinant which has that gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::0b3b2788ec4de81c7e3ed614ea6c169f
https://www.bib.irb.hr/35077
https://www.bib.irb.hr/35077
Autor:
Petković, Hrvoje, Thamchaipenet, Arinthip, Zhou, Lihong, Hranueli, Daslav, Raspor, Peter, Waterman, G. Peter, Hunter, S. Iain
Oxytetracycline is a polyketide antibiotic made by Streptomyces rimosus. From DNA sequencing, the gene product of otcD1 is deduced to function as a bifunctional cyclase/aromatase involved in ring closure of the polyketide backbone. Although otcD1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::5d8508487ea46d5235bb6d5431c3c756
https://www.bib.irb.hr/37606
https://www.bib.irb.hr/37606
The oxytetracycline (OTC) gene cluster lies about 600 kb from the end of the linear chromosome of S. rimosus and mutants that have lost the cluster (Class II mutants) occur at a frequency of up to 1% of spores. These deletion mutants have lost about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::8c18d1de7f67e60dbd64e3c07d7e9d5d
https://www.bib.irb.hr/35078
https://www.bib.irb.hr/35078
Autor:
Perić, Nataša, Petković, Hrvoje, Toman, Zora, Pigac, Jasenka, Paravić, Andrea, Cullum, John, Hunter, S. Iain, Hranueli, Daslav
The oxytetracycline (OTC) gene cluster of S. rimosus R6 lies about 600 kb from one end of the linear chromosome in an amplifiable unit of DNA (AUD) (Pandza et al., Microbiol. 143, 1493, 1997). Constructs were designed to introduce disruptions or dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::30f6bd459b8c1cead8a32021a97890ef
https://www.bib.irb.hr/35073
https://www.bib.irb.hr/35073
Autor:
Petković, Hrvoje, Perić, Nataša, Zhou, Lihong, Borovička, Branko, Waterman, G. Peter, Hranueli, Daslav, Hunter, S. Iain
The entire gene cluster for oxytetracycline (OTC) biosynthesis has been cloned from S. rimosus.1 A strategy to deduce the function of each gene is to identify the metabolite(s) made by a recombinant which has that gene disrupted.2 Gene disruptions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::647c30902deaaa927b1cdf13e4cb3dd5
https://www.bib.irb.hr/35069
https://www.bib.irb.hr/35069
Autor:
Petković, Hrvoje, Zhou, Lihong, Raspor, Peter, Waterman, G. Peter, Hranueli, Daslav, Hunter, S. Iain
Celotna skupina genov za biosinteze oksitetraciklina (OTC) iz S. rimosus je že klonirana. Eden od načinov, da sa določi vloga določenega gena is skupine genov za biosintezo OTC je, da se identificira metabolit ali metaboliti, katere producira rek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::a60d05725fe3891716ad214ef47b2937
https://www.bib.irb.hr/35068
https://www.bib.irb.hr/35068