Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.

Autor: Mazur M; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Olczak J; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Olejniczak S; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Koralewski R; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Czestkowski W; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Jedrzejczak A; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Golab J; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland.; Department of Immunology, Medical University of Warsaw , 1A Banacha Str., 02-097 Warsaw, Poland., Dzwonek K; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Dymek B; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Sklepkiewicz PL; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Zagozdzon A; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Noonan T; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Mahboubi K; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Conway B; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Sheeler R; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland., Beckett P; The Institute for Pharmaceutical Discovery , Business Drive 23, Branford, Connecticut 06405, United States., Hungerford WM; The Institute for Pharmaceutical Discovery , Business Drive 23, Branford, Connecticut 06405, United States., Podjarny A; Department of Integrative Biology, IGBMC, CNRS, INSERM, Université de Strasbourg , 1 Rue Laurent Fries, 67404 Illkirch, France., Mitschler A; Department of Integrative Biology, IGBMC, CNRS, INSERM, Université de Strasbourg , 1 Rue Laurent Fries, 67404 Illkirch, France., Cousido-Siah A; Department of Integrative Biology, IGBMC, CNRS, INSERM, Université de Strasbourg , 1 Rue Laurent Fries, 67404 Illkirch, France., Fadel F; Department of Integrative Biology, IGBMC, CNRS, INSERM, Université de Strasbourg , 1 Rue Laurent Fries, 67404 Illkirch, France., Golebiowski A; OncoArendi Therapeutics SA , Żwirki i Wigury 101, 02-089 Warsaw, Poland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 695-710. Date of Electronic Publication: 2018 Jan 11.

Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.

Autor: Arcari JT; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, United States., Beebe JS, Berliner MA, Bernardo V, Boehm M, Borzillo GV, Clark T, Cohen BD, Connell RD, Frost HN, Gordon DA, Hungerford WM, Kakar SM, Kanter A, Keene NF, Knauth EA, Lagreca SD, Lu Y, Martinez-Alsina L, Marx MA, Morris J, Patel NC, Savage D, Soderstrom CI, Thompson C, Tkalcevic G, Tom NJ, Vajdos FF, Valentine JJ, Vincent PW, Wessel MD, Chen JM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 May 15; Vol. 23 (10), pp. 3059-63. Date of Electronic Publication: 2013 Mar 21.