Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions.

Autor: Flickinger KM; Morgridge Institute for Research, Madison, WI 53715, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Wilson KM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Rossiter NJ; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA., Hunger AL; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Vishwasrao PV; Division of Hematology, Oncology, and Bone Marrow Transplant, University of Wisconsin-Madison, Madison, WI 53706, USA., Lee TD; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Mellado Fritz CA; Morgridge Institute for Research, Madison, WI 53715, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Richards RM; Division of Hematology, Oncology, and Bone Marrow Transplant, University of Wisconsin-Madison, Madison, WI 53706, USA., Hall MD; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Cantor JR; Morgridge Institute for Research, Madison, WI 53715, USA.; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53792, USA.

Publikováno v: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eadq3591. Date of Electronic Publication: 2024 Oct 04.