Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hung-Sia Teh"'
Publikováno v:
Paradoxes in Immunology ISBN: 9780429286353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce73897b70ebcdf1ca9dd53f083473ed
https://doi.org/10.1201/9780429286353-13
https://doi.org/10.1201/9780429286353-13
Publikováno v:
European Journal of Immunology. 41:335-344
Members of the TNF and TNF receptor (TNFR) superfamily play important roles in the maintenance of homeostasis of the immune system. Furthermore, several members of the TNFR family participate in T-cell activation and sustaining T-cell responses. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0393472a7cdb647ab93eac88df75c31b
https://doi.org/10.1002/eji.201040639
https://doi.org/10.1002/eji.201040639
Autor:
Hung Sia Teh, Lauren A. Zenewicz, Xiaoxi Chen, John J. Priatel, James C. Stone, Hao Shen, Jason J. Coughlin, Michael T. Chow, Rusung Tan, Yu-Hsuan Huang
Publikováno v:
The Journal of Immunology. 184:666-676
Ag encounter by naive CD8 T cells initiates a developmental program consisting of cellular proliferation, changes in gene expression, and the formation of effector and memory T cells. The strength and duration of TCR signaling are known to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8e0a646b73858375779b831d602f68
https://doi.org/10.4049/jimmunol.0803521
https://doi.org/10.4049/jimmunol.0803521
Publikováno v:
The Journal of Immunology. 180:5973-5982
RasGRP1 and Sos are two Ras-guanyl-nucleotide exchange factors that link TCR signal transduction to Ras and MAPK activation. Recent studies demonstrate positive selection of developing thymocytes is crucially dependent on RasGRP1, whereas negative se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80b0b98eed8c796749c17ef01b424c1
https://doi.org/10.4049/jimmunol.180.9.5973
https://doi.org/10.4049/jimmunol.180.9.5973
Autor:
Lauren A. Zenewicz, Xiaoxi Chen, John J. Priatel, Hung Sia Teh, Marc S. Horwitz, Kenneth W. Harder, Hao Shen
Publikováno v:
The Journal of Immunology. 179:2143-2152
The Ras-guanyl nucleotide exchange factor RasGRP1 is an important link between TCR-mediated signaling and the activation of Ras and its downstream effectors. RasGRP1 is especially critical for the survival and differentiation of developing thymocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf351a85152f8e6f9735a58987f882d2
https://doi.org/10.4049/jimmunol.179.4.2143
https://doi.org/10.4049/jimmunol.179.4.2143
Autor:
Melissa C. Ma, Hung-Sia Teh, Lisa C. Osborne, Jonathan W. Snow, M. Jill Miners, John J. Priatel, Ninan Abraham, Salim Dhanji, Mark A. Goldsmith
Publikováno v:
The Journal of Experimental Medicine
Loss of interleukin (IL)-7 or the IL-7 receptor alpha (IL-7Ralpha, CD127) results in severe immunodeficiencies in mice and humans. To more precisely identify signals governing IL-7 function in vivo, we have disrupted the IL-7Ralpha Y449XXM motif in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d261b1d27c694297700b1afe4cc0e07
https://doi.org/10.1084/jem.20061871
https://doi.org/10.1084/jem.20061871
Publikováno v:
The Journal of Immunology. 177:5098-5104
H2-M3-restricted CD8+ T cells provide early protection against bacterial infections. In this study, we demonstrate that activated H2-M3-restricted T cells provide early signals for efficient CD4+ T cell priming. C57BL/6 mice immunized with dendritic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e9432dfa3ad210d0df206e2bc20ac7
https://doi.org/10.4049/jimmunol.177.8.5098
https://doi.org/10.4049/jimmunol.177.8.5098
Publikováno v:
Scopus-Elsevier
TCR signaling plays a governing role in both the survival and differentiation of bipotent double-positive thymocytes into the CD4+ and CD8+ single-positive T cell lineages. A central mediator of this developmental program is the small GTPase Ras, emi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9867aeb7990471ce885c4e2f4e306682
https://doi.org/10.4049/jimmunol.177.3.1470
https://doi.org/10.4049/jimmunol.177.3.1470
Publikováno v:
The Journal of Immunology. 177:138-146
Self-specific CD8 T cells, which are selected by high-affinity interactions with self-Ags, develop into a lineage distinct from conventional CD8 T cells. We have previously shown that these self-specific cells acquire phenotypic and functional simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf2045f67ac938161c169ab3a276eb1
https://doi.org/10.4049/jimmunol.177.1.138
https://doi.org/10.4049/jimmunol.177.1.138
Publikováno v:
The Journal of Immunology. 176:1026-1035
Naive T cells require costimulation for robust Ag-driven differentiation and survival. Members of the TNFR family have been shown to provide costimulatory signals conferring survival at distinct phases of the T cell response. In this study, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9f13b052766ad9e0f05907d0e20f72
https://doi.org/10.4049/jimmunol.176.2.1026
https://doi.org/10.4049/jimmunol.176.2.1026