Výsledky vyhledávání

Akademický článek

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

Autor: Hung-Pin Peng, Hung-Ju Hsu, Chung-Ming Yu, Fei-Hung Hung, Chao-Ping Tung, Yu-Chuan Huang, Chi-Yung Chen, Pei-Hsun Tsai, An-Suei Yang

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces. In this work, we elucidate, with computational ana

Externí odkaz: https://doaj.org/article/cf8c2be118304f39a2bf41df25be8e70

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates (ADCs) targeting MSLN have be

Externí odkaz: https://doaj.org/article/1fd9e8c33c85491783497a53a3cfc809

Zobrazit plný text záznamu

Plný text ve formátu HTML

Tumor-Targeting Ability of Novel Anti-Prostate-Specific Membrane Antigen Antibodies

Autor: Hsin-Hua Hsieh, Wei-Ying Kuo, Jia-Jia Lin, Hong-Sen Chen, Hung-Ju Hsu, Chun-Yi Wu

Publikováno v: ACS Omega. 7:31529-31537

Patients with prostate-specific membrane antigen (PSMA)-positive tumors can benefit from PSMA-targeted therapy; thus, we have constructed a phage-displayed synthetic antibody library for the production of novel PSMA antibodies with superior PSMA-targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb6c1d740e9160d0de19ed698ce1d9a
https://doi.org/10.1021/acsomega.2c04230

Zobrazit plný text záznamu

Functionalized Terpolymer-Brush-Based Biointerface with Improved Antifouling Properties for Ultra-Sensitive Direct Detection of Virus in Crude Clinical Samples

Publikováno v: ACS Applied Materials & Interfaces. 13:60612-60624

New analytical techniques that overcome major drawbacks of current routinely used viral infection diagnosis methods, i.e., the long analysis time and laboriousness of real-time reverse-transcription polymerase chain reaction (qRT-PCR) and the insuffi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df4e8ea183952e1d6e85d9f012353d
https://doi.org/10.1021/acsami.1c16930

Zobrazit plný text záznamu

Akademický článek

書寫文化、學校課程與階級再製：當代法國教育社會學對P. Bourdieu 文化資本

Autor: 許宏儒Hung-Ju Hsu

Publikováno v: Journal of Curriculum Studies, Vol 10, Iss 1, Pp 35-49 (2015)

本研究探討「書寫文化」在學校課程與階級再製當中所扮演的角色。法國社會學家P. Bourdieu的文化資本（le capital culturel）理論揭示了學校課程當中造成階級再製的細微運作原因，但他並未深�

Externí odkaz: https://doaj.org/article/0ae6228070c94dd99ffad02dc52fc981

Zobrazit plný text záznamu

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates (ADCs) targeting MSLN have been demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a483abbcadb81e6aa556a2671f32fb7e
https://doaj.org/article/1fd9e8c33c85491783497a53a3cfc809

Zobrazit plný text záznamu

Plný text ve formátu HTML

Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities

Autor: Ing-Chien Chen, Tung Chao-Ping, Hung-Pin Peng, Kuo Wei-Ying, Jhih-Wei Jian, Yu Chung-Ming, Chiu Yi-Kai, An-Suei Yang, Yueh-Liang Tsou, Hong-Sen Chen, Hung-Ju Hsu

Publikováno v: mAbs

Antibodies provide immune protection by recognizing antigens of diverse chemical properties, but elucidating the amino acid sequence-function relationships underlying the specificity and affinity of antibody-antigen interactions remains challenging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0af14b3ae4daec1c789ae8710bc94
http://europepmc.org/articles/PMC6380391

Zobrazit plný text záznamu

Akademický článek

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface.

Autor: Chung-Ming Yu, Hung-Pin Peng, Ing-Chien Chen, Yu-Ching Lee, Jun-Bo Chen, Keng-Chang Tsai, Ching-Tai Chen, Jeng-Yih Chang, Ei-Wen Yang, Po-Chiang Hsu, Jhih-Wei Jian, Hung-Ju Hsu, Hung-Ju Chang, Wen-Lian Hsu, Kai-Fa Huang, Alex Che Ma, An-Suei Yang

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33340 (2012)

Protein-protein interactions are critical determinants in biological systems. Engineered proteins binding to specific areas on protein surfaces could lead to therapeutics or diagnostics for treating diseases in humans. But designing epitope-specific

Externí odkaz: https://doaj.org/article/edd7680d33c84d8898a3b06986ae60b4

Zobrazit plný text záznamu