Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hung X. Nguyen"'
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f565703737de4d078598a60ba6a31e7c
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size
Externí odkaz:
https://doaj.org/article/e4a62bc25c4744e394d6e8b834aeeb8e
Publikováno v:
IEEE Access, Vol 6, Pp 61212-61222 (2018)
Next generation 5G cellular networks will consist of multiple technologies for devices to access the network at the edge. One of the keys to 5G is, therefore, the ability of devices to intelligently select its radio access technology (RAT). There hav
Externí odkaz:
https://doaj.org/article/b1b905fc75df4f32a72e3df01bcc9188
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excita
Externí odkaz:
https://doaj.org/article/01169a26b7fb41869b421987bafb38d4
Autor:
Nenad Bursac, Hung X Nguyen
Publikováno v:
Curr Opin Biotechnol
Ion channels play essential roles in regulating electrical properties of excitable tissues. By leveraging various ion channel gating mechanisms, scientists have developed a versatile set of genetically encoded tools to modulate intrinsic tissue excit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462ffd051f83ef9caaabcce4c43c4303
https://doi.org/10.1016/j.copbio.2019.01.004
https://doi.org/10.1016/j.copbio.2019.01.004
Publikováno v:
Methods in Enzymology ISBN: 9780128239247
Methods Enzymol
Methods Enzymol
Sudden cardiac death continues to have a devastating impact on public health prompting the continued efforts to develop more effective therapies for cardiac arrhythmias. Among different approaches to normalize function of ion channels and prevent arr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1941d41796f34ad37ec22380cdd1aa
https://doi.org/10.1016/bs.mie.2021.03.008
https://doi.org/10.1016/bs.mie.2021.03.008
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8817c52c5109b567d23bb74f0aba6
https://pubmed.ncbi.nlm.nih.gov/35110560
https://pubmed.ncbi.nlm.nih.gov/35110560
Publikováno v:
Nature Protocols. 13:927-945
We describe a two-stage protocol to generate electrically excitable and actively conducting cell networks with stable and customizable electrophysiological phenotypes. Using this method, we have engineered monoclonally derived excitable tissues as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2492e11e2666551f786596a5c91196e
https://doi.org/10.1038/nprot.2018.016
https://doi.org/10.1038/nprot.2018.016
Publikováno v:
Theranostics
Our knowledge of pluripotent stem cell biology has advanced considerably in the past four decades, but it has yet to deliver on the great promise of regenerative medicine. The slow progress can be mainly attributed to our incomplete understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b183f076158dc4d8ee3b0cbed73cef6
http://europepmc.org/articles/PMC5596442
http://europepmc.org/articles/PMC5596442
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
The ability to directly enhance electrical excitability of human cells is hampered by the lack of methods to efficiently overexpress large mammalian voltage-gated sodium channels (VGSC). Here we describe the use of small prokaryotic sodium channels (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de47c6898d0dc1fa257b78c0a0ff3772
https://doi.org/10.1038/ncomms13132
https://doi.org/10.1038/ncomms13132