Effect of Oxidative Stress Induced by L-Dopa on Endogenous Antioxidants in PC-12 Cells

Autor: Hung T. Quach, W. Ed Smith, Govind T. Vatassery

Publikováno v: Annals of the New York Academy of Sciences. 1074:330-336

The mechanism of action of many drugs of abuse involves the dopaminergic pathway. One method of increasing dopamine in brain is by ingestion of L-dopa (3,4-dihydroxy-L-phenylalanine). Interestingly, both dopamine and L-dopa cause oxidative stress whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd426c008b741d02a0692fad948e1f1
https://doi.org/10.1196/annals.1369.030

Alpha and Gamma Tocopherols in Cerebrospinal Fluid and Serum from Older, Male, Human Subjects

Autor: Govind T. Vatassery, W. Ed Smith, Hung T. Quach, Dean Melnyk, Michael A. Kuskowski, Adityanjee

Publikováno v: Journal of the American College of Nutrition. 23:233-238

The major forms of vitamin E in human physiological fluids are alpha and gamma tocopherols which exhibit different biological activities under a variety of assay conditions. The goal of this study was to obtain indirect information about the transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562428d4359449253e3f94c6571de0ce
https://doi.org/10.1080/07315724.2004.10719366

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Autor: Hung T. Quach, James C. K. Lai, W. E. Smith, Govind T. Vatassery

Publikováno v: Neurochemical Research. 23:121-125

We examined the influence of aging upon the uptake of glutamate by synaptosomes, and the oxidation of Synaptosomal vitamin E. Synaptosomes isolated from the cerebral hemispheres of Fischer 344 rats, 4 and 24 months old, were suspended at 37°C in buf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ae2e1f3fb9fce66309b4c004cad24ee
https://doi.org/10.1023/a:1022495804817

Brains of apolipoprotein E deficient mice fed vitamin E deficient diets show alteration in handling alpha tocopherol injected into the cerebral ventricles

Autor: Hung T. Quach, W. Ed Smith, Govind T. Vatassery

Publikováno v: Journal of the neurological sciences. 283(1-2)

Abnormal function of apolipoprotein E (apoE) has been implicated in the incidence of some neurological disorders including dementia. Our recent experiments have shown that apoE deficiency alters the dynamics of alpha tocopherol (vitamin E) handling b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c05581c4dd1d48c034f41af78737cfd
https://pubmed.ncbi.nlm.nih.gov/19446300

Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system

Autor: Saji Oommen, Kishorchandra Gohil, Vihas T. Vasu, Bettina C. Schock, Carroll E. Cross, Hnin Hnin Aung, Hung T. Quach, Govind T. Vatassery

Publikováno v: Gohil, K, Oommen, S, Quach, H T, Vasu, V T, Aung, H H, Schock, B, Cross, C E & Vatassery, B T 2008, ' Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system ' Brain Research, vol. 1201, pp. 167-176 . DOI: 10.1016/j.brainres.2008.01.044

Ataxia with vitamin E deficiency is caused by mutations in alpha-tocopherol transfer protein (alpha-TTP) gene and it can be experimentally generated in mice by alpha-TTP gene inactivation (alpha-TTP-KO). This study compared alpha-tocopherol (alpha-T)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d730c71ca477c8d7176c081a2d148db6
https://pubmed.ncbi.nlm.nih.gov/18299118