Výsledky vyhledávání - "Hung Sheng Tan"

Memory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution

Autor: Jennifer M. McNiff, Catherine Matte-Martone, Srividhya Venkatesan, Warren D. Shlomchik, Derry C. Roopenian, Ning Li, Susan M. Kaech, Weiguo Cui, Hung Sheng Tan, Hong Zheng, Anthony J. Demetris

Publikováno v: Blood. 118:5965-5976

Donor T cells contribute to the success of allogeneic hematopoietic stem cell transplantation (alloSCT). Alloreactive donor T cells attack leukemia cells, mediating the GVL effect. Donor T cells, including the memory T cells (TM) that are generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc285e64f0f6fba7226ef827f6da0c0
https://doi.org/10.1182/blood-2011-07-367011

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Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease

Autor: Hung Sheng Tan, Hong Zheng, Srividhya Venketesan, Warren D. Shlomchik, Britt E. Anderson, Jennifer M. McNiff, Dhanpat Jain, Hongmei Li, Catherine Matte-Martone

Publikováno v: Blood. 111:2476-2484

Much of the efficacy of allogeneic hematopoietic stem cell transplantation (alloSCT) in curing hematologic malignancies is due to a graft-versus-leukemia (GVL) effect mediated by donor T cells that recognize recipient alloantigens on leukemic cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f1733661add71864b609fc2cd8330d
https://doi.org/10.1182/blood-2007-08-109678

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Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction

Autor: Jennifer M. McNiff, Hung Sheng Tan, Warren D. Shlomchik, David M. Rothstein, Anthony J. Demetris, Catherine Matte-Martone, Fadi G. Lakkis, Hongmei Li

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 188(8)

The efficacy of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-host disease (GVHD). Host hematopoietic APCs are important initiators of GVHD, making them logical targets for GVHD prevention. Conventional dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e35080b66737e67c85ffebdcec0a16
https://pubmed.ncbi.nlm.nih.gov/22422880

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Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation

Autor: Derry C. Roopenian, Hung Sheng Tan, Ning Li, Warren D. Shlomchik, Weiguo Cui, Xiaojian Wang, Hongmei Li, Catherine Matte-Martone

Publikováno v: Blood. 118(24)

Recipient antigen-presenting cells (APCs) initiate GVHD by directly presenting host minor histocompatibility antigens (miHAs) to donor CD8 cells. However, later after transplantation, host APCs are replaced by donor APCs, and if pathogenic CD8 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca03a83373a21faeb56d172f1bdee10
https://pubmed.ncbi.nlm.nih.gov/21963602

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Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant

Autor: Srividhya Venkatesan, Warren D. Shlomchik, Julia Chang, Jovana Pavisic, Catherine Matte-Martone, Hung Sheng Tan, Ioanna Athanasiadis

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 187(4)

Graft-versus-leukemia (GVL) against chronic-phase chronic myelogenous leukemia (CP-CML) is potent, but it is less efficacious against acute leukemias and blast-crisis chronic myelogenous leukemia (BC-CML). The mechanisms underlying GVL resistance are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c622da1a2440e31a8244c26f0afcef4
https://pubmed.ncbi.nlm.nih.gov/21768400

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Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells

Autor: Catherine Matte-Martone, Warren D. Shlomchik, Jennifer M. McNiff, Srividhya Venkatesan, Hongmei Li, Fadi G. Lakkis, Hung Sheng Tan, Anthony J. Demetris, Dhanpat Jain, David M. Rothstein

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 186(1)

Graft-versus-host disease (GVHD) is initiated by APCs that prime alloreactive donor T cells. In antipathogen responses, Ag-bearing APCs receive signals through pattern-recognition receptors, including TLRs, which induce the expression of costimulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eec7756b72ebd3fafbd88a6f66c8b1b
https://pubmed.ncbi.nlm.nih.gov/21098219

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Langerhans cells are not required for graft-versus-host disease

Autor: Jennifer M. McNiff, Catherine Matte-Martone, Hongmei Li, Hung Sheng Tan, Mark J. Shlomchik, Srividhya Venkatesan, Warren D. Shlomchik, Anthony J. Demetris, Daniel H. Kaplan, Kody L. Johnson

Publikováno v: Blood. 117(2)

Graft-versus-host disease (GVHD) is initiated and maintained by antigen-presenting cells (APCs) that prime alloreactive donor T cells. APCs are therefore attractive targets for GVHD prevention and treatment. APCs are diverse in phenotype and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e7eb3ddf8fadd6858d331f0d27d05b
https://pubmed.ncbi.nlm.nih.gov/20944073

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know

Autor: Hung Sheng Tan, Guangwen Ren, Gobardhan Das, Yufang Shi, Arthur I. Roberts, Guangwu Xu, Liying Zhang, Jyoti Das, Catherine H. Liu, Yingyu Zhang, Zeng Rong Yuan, Satish Devadas

Publikováno v: Cell research. 16(2)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286885a6844af42140b3f3ec53f548b0
https://pubmed.ncbi.nlm.nih.gov/16474424

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Graft-Versus-Host-Disease Recruits Both Monocyte and Pre-Conventional Dendritic Cell-Derived Tissue Antigen Presenting Cells Independent Of CCR2 and CCR6

Autor: David M. Rothstein, Fadi G. Lakkis, Warren D. Shlomchik, Catherine Matte-Martone, Christian A. Wysocki, Hung Sheng Tan, Kathryn W Juchem, Sarah Morin-Zorman, Srividhya Venkatesan

Publikováno v: Blood. 122:4463-4463

Graft-versus-host disease (GVHD) limits the broader application of allogeneic hematopoietic stem cell transplantation. In prior studies we defined roles for both host and donor-derived antigen presenting cells (APCs) in the activation of alloreactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8c3074fbcd1f8c1a6074d3545068cc4
https://doi.org/10.1182/blood.v122.21.4463.4463

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Akademický článek

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells.

Autor: Hongmei Li^1,2, Matte-Martone, Catherine^1,2, Hung Sheng Tan^1,2, Venkatesan, Srividhya³, McNiff, Jennifer^4,5, Demetris, Anthony J.⁶, Jain, Dhanpat⁷, Lakkis, Fadi⁵, Rothstein, David⁵, Shlomchik, Warren D.^1,2 warren.shlomchik@yale.edu

Publikováno v: Journal of Immunology. 1/1/2011, Vol. 186 Issue 1, p230-241. 12p.

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