Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hung Jocelyn H"'
Autor:
Hung Jocelyn H, Leslie M. Werbel, Margaret J. Degnan, Daniel F. Ortwine, Dennis Joseph Mcnamara, Susan E. Uhlendorf, Stephen J. Kesten
Publikováno v:
Journal of Medicinal Chemistry. 35:3429-3447
To improve upon the activity and properties of the 3-aryl-7-chloro-3,4- dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and
Autor:
Judith L. Johnson, Edward F. Elslager, Leslie M. Werbel, Stephen J. Kesten, Donald F. Worth, Daniel F. Ortwine, Dennis Joseph Mcnamara, Hung Jocelyn H, P. Dan Cook
Publikováno v:
Journal of Medicinal Chemistry. 29:924-939
A series of 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides was prepared from the substituted 1-phenyl-2-propanones proceeding through the 5-nitro[1,1'-biphenyl]-2-ols, the corresponding amino, and ace
Publikováno v:
Journal of Heterocyclic Chemistry. 20:1575-1580
7-Chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1H-thioxanthene-1,9 (2H)-dione (10), and a variety of analogs and derivatives were prepared as sulfur isosteric analogs of the acridinedione antimalarial agent, floxacrine. The compounds were devoid of anti
Autor:
Hung Jocelyn H, Leslie M. Werbel
Publikováno v:
Journal of Heterocyclic Chemistry. 21:741-744
The synthesis of 6-ethyl-5-(4-pyridinyl)-2,4-pyrimidinediamine (2), the pyridine analog of pyrimethamine, is described. Condensation of 4-pyridineacetonitrile (3) with methyl propionate afforded α-(1-oxopropyl)-4-pyridineacetonitrile (4). Treatment
Autor:
Hung Jocelyn H, Leslie M. Werbel
Publikováno v:
Synthesis. 1985:80-81